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miR-196, an Emerging Cancer Biomarker for Digestive Tract Cancers
Ya-Ching Lu1, Joseph T Chang2, Err-Cheng Chan1
11. Department of Medical Biotechnology and Laboratory science, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan;
Abstract:
Over the past decade, the emergence of microRNA (miRNA) research has firmly established this molecular family as a key component in cells. MiRNAs, which function as negative gene regulators, participate in multiple biological processes and maintain homeostasis in cells. The dysregulation of miRNA may contribute to numerous human disorders, including cancer. Recently, miR-196 was found to be aberrantly expressed in a wide range of malignant diseases, which suggests that it plays important roles in carcinogenesis. Here, we summarize the current knowledge concerning miR-196 family in cancers. This review includes miR-196 gene structure and aberrant expression in various cancers, and current understanding of numerous functions and regulatory targets of miR-196 in specific cancers. Since miR-196 are consistently found over-expressed in digestive tract cancer tissues, we also reviewed the clinical significance and potential applications of miR-196 in these cancers. We highlight that miR-196 may serve as an emerging cancer biomarker for digestive tract cancers.
Insights
MicroRNAs (miRNAs) are key gene regulators. Aberrant expression of miR-196 in cancers, particularly digestive tract cancers, suggests its role in carcinogenesis and potential as a diagnostic biomarker.
Area of Science:
- Molecular Biology
- Genetics
- Oncology
Background:
- MicroRNAs (miRNAs) are crucial negative gene regulators involved in cellular homeostasis.
- Dysregulated miRNA expression is linked to various human diseases, including cancer.
- miR-196 has emerged as a significantly aberrantly expressed molecule in multiple malignancies.
Purpose of the Study:
- To review the current understanding of the miR-196 family in cancer.
- To explore miR-196 gene structure, aberrant expression, functions, and targets in various cancers.
- To investigate the clinical significance and biomarker potential of miR-196 in digestive tract cancers.
Main Methods:
- Literature review of miR-196 family in cancer research.
- Analysis of miR-196 gene structure and expression patterns.
- Examination of miR-196 functions and regulatory targets.
- Evaluation of clinical data regarding miR-196 in digestive tract cancers.
Main Results:
- miR-196 family members exhibit aberrant expression across a spectrum of cancers.
- miR-196 plays significant roles in the processes of carcinogenesis.
- Consistent overexpression of miR-196 is observed in digestive tract cancer tissues.
Conclusions:
- miR-196 is implicated in the development and progression of various cancers.
- miR-196 holds potential as a valuable biomarker for early detection and prognosis in digestive tract cancers.
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