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Related Experiment Video

Updated: Mar 22, 2026

Thoracoscopic Extended Right Middle Plus Lower Sleeve Lobectomy for Non-Small-Cell Lung Cancer
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Video-assisted thoracoscopic surgery lobectomy for lung cancer versus thoracotomy: a less decrease in sVEGFR2 level

Jun Peng1, Su An1, Hui-Ping Wang1

  • 11 Department of Thoracic Surgery, The First People's Hospital of Yunnan Province, Kunming University of Science and Technology, Kunming 650032, China ; 2 Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China ; 3 Children's Hospital Affiliated to Kunming Medical University, Kunming 650228, China.

Journal of Thoracic Disease
|April 15, 2016
PubMed
Summary
This summary is machine-generated.

Video-assisted thoracoscopic surgery (VATS) lobectomy for lung cancer increases soluble vascular endothelial growth factor (VEGF) receptor 2 (sVEGFR2) levels more than open thoracotomy. This enhanced anti-angiogenic response may impact cancer recurrence.

Keywords:
Video-assisted thoracoscopicantiangiogenic factorsthoracotomy

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Area of Science:

  • Oncology
  • Thoracic Surgery
  • Molecular Biology

Background:

  • Angiogenic and anti-angiogenic factors are crucial in tumor biology and recurrence.
  • Soluble vascular endothelial growth factor (VEGF) receptors, sVEGFR1 and sVEGFR2, regulate angiogenesis by sequestering VEGF.
  • Surgical resection for non-small cell lung cancer (NSCLC) can influence these angiogenic factors.

Purpose of the Study:

  • To compare the impact of video-assisted thoracoscopic surgery (VATS) lobectomy versus open thoracotomy (OT) on postoperative circulating sVEGFR1 and sVEGFR2 levels in early-stage NSCLC patients.
  • To investigate the role of surgical approach in modulating the anti-angiogenic response post-pulmonary resection.

Main Methods:

  • A cohort of 48 early-stage NSCLC patients underwent either VATS (n=26) or OT (n=22) lobectomy.
  • Plasma levels of sVEGFR1 and sVEGFR2 were measured using ELISA preoperatively and on postoperative days 1, 3, and 7.
  • Statistical analysis was performed using the Wilcoxon signed-Rank test.

Main Results:

  • Postoperative sVEGFR1 levels increased on days 1 and 3, while sVEGFR2 levels decreased on days 1 and 3 in all lobectomy patients.
  • Patients undergoing VATS demonstrated significantly higher plasma sVEGFR2 levels on postoperative day 1 compared to those who underwent OT (VATS: 6,953±1,535 pg/mL vs. OT: 5,874±1,328 pg/mL, P<0.05).

Conclusions:

  • Major pulmonary resection for NSCLC alters the balance of angiogenic factors, increasing sVEGFR1 and decreasing sVEGFR2.
  • VATS lobectomy is associated with a stronger anti-angiogenic response, evidenced by higher postoperative sVEGFR2 levels compared to OT.
  • These differences in anti-angiogenic profiles may influence lung cancer biology and postoperative recurrence rates.