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Updated: Mar 22, 2026

Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome ARDS
Published on: April 7, 2021
Personalizing mechanical ventilation for acute respiratory distress syndrome
S Clark Berngard1, Jeremy R Beitler1, Atul Malhotra1
1Division of Pulmonary and Critical Care Medicine, University of California, San Diego, La Jolla, CA, USA.
Abstract:
Lung-protective ventilation with low tidal volumes remains the cornerstone for treating patient with acute respiratory distress syndrome (ARDS). Personalizing such an approach to each patient's unique physiology may improve outcomes further. Many factors should be considered when mechanically ventilating a critically ill patient with ARDS. Estimations of transpulmonary pressures as well as individual's hemodynamics and respiratory mechanics should influence PEEP decisions as well as response to therapy (recruitability). This summary will emphasize the potential role of personalized therapy in mechanical ventilation.
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