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Updated: Mar 22, 2026
A "Plug-And-Display" Nanoparticle Vaccine Platform Based on Outer Membrane Vesicles Displaying SARS-CoV-2 Receptor-Binding Domain
Published on: July 25, 2022
Multilayer engineered nanoliposomes as a novel tool for oral delivery of lipopeptide-based vaccines against group A
Nirmal Marasini1, Ashwini K Giddam1, Khairunnisa A Ghaffar1
1School of Chemistry & Molecular Biosciences, The University of Queensland, St Lucia, QLD 4072, Australia.
Aim:
To develop an oral nanovaccine delivery system for lipopeptide-based vaccine candidate against group A Streptococcus.
Materials & Methods:
Lipid-core peptide-1-loaded nanoliposomes were prepared as a template and coated with opposite-charged polyelectrolytes to produce particles with size <200 nm. Efficacy of this oral nanovaccine delivery system was evaluated in mice model.
Results:
Polymer-coated liposomes produced significantly higher antigen-specific mucosal IgA and systemic IgG titers in comparison to vaccine formulated with a strong mucosal adjuvant upon oral immunization in mice. Moreover, high levels of systemic antibody titers were retained even at day 185 postprimary immunization.
Conclusion:
Efficient oral delivery platform for lipopeptide-based vaccines has been developed.
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