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Chronic Pancreatitis: Landmark Papers, Management Decisions, and Future
Eugene P DiMagno1, Matthew J DiMagno
1From the *Department of Internal Medicine, Division of Gastroenterology and Hepatology, Mayo Medical School, Mayo Clinic, Rochester, MN; and †Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan School of Medicine, Ann Arbor, MI.
Pancreas
|April 15, 2016
Summary
This review covers landmark papers influencing chronic pancreatitis (CP) management, including its subtypes, genetic factors, and complications like pancreatic cancer and exocrine insufficiency. Future research directions are also suggested.
Area of Science:
- Gastroenterology
- Hepatology
- Digestive Diseases
Background:
- Chronic pancreatitis (CP) management is complex, requiring understanding of its diverse etiologies and natural history.
- Landmark research significantly shapes current clinical practice for CP.
- Distinguishing CP from recurrent acute pancreatitis is crucial for appropriate patient care.
Purpose of the Study:
- To review pivotal studies impacting the modern management of chronic pancreatitis.
- To discuss key aspects of CP, including etiology, diagnosis, and complications.
- To propose future research directions in the field of chronic pancreatitis.
Main Methods:
- Review of landmark publications in chronic pancreatitis.
- Discussion of duct anatomy, pancreas divisum, and pancreatitis classifications.
- Analysis of natural history, genetic discoveries, and associated conditions.
Main Results:
- Established CP (ECP) requires differentiation from recurrent acute pancreatitis.
- Alcoholic, idiopathic, and hereditary pancreatitis have distinct natural histories and genetic links.
- Pancreatic cancer risk and exocrine insufficiency are significant CP complications.
Conclusions:
- Modern CP management benefits from understanding historical research and current evidence.
- Further research is needed to refine diagnosis, treatment, and understanding of CP pathogenesis.
- Future directions include advancements in endoscopic diagnostics and understanding autoimmune pancreatitis.
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