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Related Experiment Video

Updated: Mar 22, 2026

In Vitro Assay to Evaluate the Impact of Immunoregulatory Pathways on HIV-specific CD4 T Cell Effector Function

In Vitro Assay to Evaluate the Impact of Immunoregulatory Pathways on HIV-specific CD4 T Cell Effector Function

Published on: October 15, 2013

NLRX1 Helps HIV Avoid a STING Operation.

Katrina B Mar¹, John W Schoggins¹

¹Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390 USA.

Cell Host & Microbe

|April 15, 2016

Summary

Nod-like receptor X1 (NLRX1) may help HIV-1 spread early in infection. This protein inhibits the innate immune response, aiding viral evasion and potentially establishing latency.

Area of Science:

Immunology
Virology
Infectious Diseases

Background:

Human Immunodeficiency Virus type 1 (HIV-1) establishes latency during acute infection, a critical step for viral persistence.
Innate immune responses are crucial for controlling viral replication and dissemination during early stages of infection.

Purpose of the Study:

To investigate the role of Nod-like receptor X1 (NLRX1) in HIV-1 immune evasion during acute infection.
To determine if NLRX1 influences the innate immune response to HIV-1.

Main Methods:

Independent studies by Barouch et al. (2016) and Guo et al. (2016) were analyzed.
The function of NLRX1 in inhibiting virus-triggered innate immune responses was examined.

Main Results:

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Last Updated: Mar 22, 2026

In Vitro Assay to Evaluate the Impact of Immunoregulatory Pathways on HIV-specific CD4 T Cell Effector Function

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Published on: October 15, 2013

Assessing the Innate Sensing of HIV-1 Infected CD4+ T Cells by Plasmacytoid Dendritic Cells Using an Ex vivo Co-culture System.

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Published on: September 1, 2015

High Throughput In Vitro Assessment of Latency Reversing Agents on HIV Transcription and Splicing

High Throughput In Vitro Assessment of Latency Reversing Agents on HIV Transcription and Splicing

Published on: January 22, 2019

NLRX1 was found to potentially inhibit the innate immune response triggered by HIV-1.
This inhibition by NLRX1 may facilitate the early systemic dissemination of HIV-1.

Conclusions:

NLRX1 plays a role in HIV-1 immune evasion during acute infection.
Inhibition of innate immunity by NLRX1 could be a mechanism for early HIV-1 spread and subsequent latency establishment.