Quantitative evaluation of cerebral white matter in patients with multiple sclerosis using multicomponent T2 mapping
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Updated: Mar 22, 2026
Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
Published on: February 19, 2021
Eva Baranovicova1, Vladimir Mlynarik2, Ema Kantorova3
1a Jessenius Faculty of Medicine, Biomedical Centre BioMed, Division of Neuroscience , Comenius University , Martin , Slovakia.
Objects:
A standard magnetic resonance imaging (MRI) investigation of white matter (WM) areas with visible or expected pathology does not explain satisfactorily the relation between pathology and clinical outcome. Therefore, we focused on multicomponent T2 mapping of WM with the intention to characterize the WM, including normal-appearing white matter that has normal and prolonged T2 and lesions, including degenerated tissue.
Materials And Methods:
Twenty-nine patients with clinically diagnosed MS and 27 healthy controls underwent MRI examination. T2 mapping of the WM across the two whole MRI slices was carried out. The relative abundance of biologically relevant T2 regions was correlated with age and the expanded disability status scale (EDSS).
Results:
The relative abundance of the T2 values of water trapped in myelin increased with age in both healthy subjects (p < 0.05) and MS patients (p < 0.05). The relative abundance of intermediate T2 assigned to intra- and extracellular water decreased with age in both groups (p < 0.05) and with EDSS (p < 0.005) in the MS patients. The mixed water pools with a T2 above 110 ms were not related to age, but strongly increased with EDSS (p < 0.000005).
Conclusion:
Our results suggest that multicomponent T2 mapping of the WM can be a useful parameter for monitoring the progression of MS in patients.
