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Related Experiment Videos

Endocarditis in an infant causing "tricuspid atresia".

S Y Ho1, C Frescura, G Thiene

  • 1Institute of Pathological Anatomy, University of Padova Medical School, Italy.

International Journal of Cardiology
|March 1, 1989
PubMed
Summary

A rare case of nonbacterial thrombotic endocarditis in an infant led to fatal tricuspid valve obstruction and heart failure. This condition, complicating disseminated intravascular coagulation, was only diagnosed post-mortem.

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Area of Science:

  • Pediatric Cardiology
  • Hematology
  • Pathology

Background:

  • Nonbacterial thrombotic endocarditis (NBE) is a rare condition characterized by sterile vegetations on heart valves.
  • Disseminated intravascular coagulation (DIC) is a serious condition involving widespread clotting and bleeding.
  • Congenital heart defects and acquired conditions can predispose infants to cardiac complications.

Observation:

  • A 3-month-old male infant presented with findings suggestive of severe cardiac compromise.
  • Post-mortem examination revealed extensive nonbacterial thrombotic endocarditis of the tricuspid valve.
  • The vegetations caused significant obstruction, mimicking tricuspid atresia.

Findings:

  • The infant's death was attributed to complications of NBE superimposed on DIC.

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  • The extensive tricuspid valve vegetations led to severe congestive right ventricular failure.
  • Diagnosis was established solely through post-mortem examination, highlighting a diagnostic challenge in vivo.

    • Implications:

    • This case underscores the critical importance of considering NBE in infants with unexplained cardiac failure and coagulopathy.
    • Early recognition and management of NBE and DIC in pediatric patients may improve outcomes.
    • Further research into the pathogenesis and diagnostic markers of NBE in infants is warranted.