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Expanded polyglutamine embedded in the endoplasmic reticulum causes membrane distortion and coincides with Bax

Masashi Ueda1, Shimo Li1, Masanori Itoh1

  • 1Department of Neurobiology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194, Japan.

Biochemical and Biophysical Research Communications
|April 16, 2016
PubMed
Summary

Polyglutamine causes endoplasmic reticulum (ER) membrane distortion, impacting cellular functions and potentially leading to neuronal cell death. This study reveals the ER membrane as a target, triggering cell death via Bax.

Keywords:
ApoptosisEndoplasmic reticulumMembranePolyglutamine

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