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The role of adiponectin in obesity-associated female-specific carcinogenesis
Ganji Purnachandra Nagaraju1, Balney Rajitha2, Sheik Aliya3
1Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA 30322, United States; Department of Biotechnology, Berhampur University, Bhanjavihar, Berhampur, Odisha 760 007, India.
Abstract:
Adipose tissue is a highly vascularized endocrine organ, and its secretion profiles may vary with obesity. Adiponectin is secreted by adipocytes that make up adipose tissue. Worldwide, obesity has been designated a serious health problem among women and is associated with a variety of metabolic disorders and an increased risk of developing cancer of the cervix, ovaries, uterus (uterine/endometrial), and breast. In this review, the potential link between obesity and female-specific malignancies is comprehensively presented by discussing significant features of the intriguing and complex molecule, adiponectin, with a focus on recent findings highlighting its molecular mechanism of action in female-specific carcinogenesis.
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