Related Experiment Video
Updated: Mar 22, 2026

Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies
Published on: January 10, 2025
Change in body mass index among girls with precocious puberty under treatment
Jessie N Zurita Cruz1,2, Irene Díaz Rodríguez3,2, Elisa Nishimura Meguro3,2
1Unidad de Investigación Médica en Epidemiología Clínica, Unidad Médica de Alta Especialidad (UMAE), Hospital de Pediatría Centro Médico Nacional Siglo XXI, Doctores, Ciudad de Mexico, D.F., 06720, México.
Introduction:
Changes in body mass index (BMI) among girls with idiopathic central precocious puberty (ICPP) under treatment have been controversial in other populations.
Objective:
To assess changes in BMI Z score and the rate of overweight and obesity in Mexican girls with ICPP during their first year of treatment.
Methodology:
A retrospective study was conducted among girls with ICPP under treatment with leuprolide, with a somatometry performed every six months, over a 1-year period. An analysis of variance (ANOVA) was done to establish differences in BMI Z score and a multivariate analysis was used to assess the relationship among the different factors.
Results:
Among 121 girls, BMI Z score increased from 0.87 to 1.32, and the rate of overweight and obesity increased from 40.5% to 70.3%, a statistically significant difference.
Conclusions:
Changes in BMI Z score and the rate of overweight and obesity among Mexican girls with ICPP increased significantly.
Related Concept Videos
Signs of Puberty
Anorexia Nervosa
Symptoms and Physical Effects
Individuals with anorexia nervosa commonly exhibit extreme...
Bulimia Nervosa
Obesity
Hormonal Regulation
Hormonal Regulation

