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[Mesiodens and heredity].

H Cadenat, R Combelles, G Fabert

    Revue De Stomatologie Et De Chirurgie Maxillo-Faciale
    |January 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Mesiodens, a rare dental anomaly, appeared in non-identical twins and their grandfather. This familial occurrence suggests a genetic basis, likely involving autosomal recessive and X-chromosome inhibition genes.

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    Area of Science:

    • Dentistry
    • Human Genetics
    • Developmental Biology

    Background:

    • Mesiodens is a supernumerary tooth located in the midline of the palate.
    • The etiology of mesiodens is not fully understood, with theories ranging from genetic factors to environmental influences.

    Observation:

    • A case study documented mesiodens in two non-identical twins and their grandfather.
    • This observation highlights a potential familial pattern of occurrence for this dental anomaly.

    Findings:

    • The high frequency of mesiodens in this family strongly suggests a hereditary component.
    • The authors propose a genetic model involving an autosomal recessive gene and an inhibitory gene on the X chromosome.
    • A spontaneous mutation theory is considered unlikely given the familial clustering.

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    Implications:

    • Understanding the genetic basis of mesiodens can aid in genetic counseling for affected families.
    • Further research into the specific genes involved could offer insights into tooth development and associated anomalies.
    • This case contributes to the evidence supporting a genetic etiology for certain dental developmental disturbances.