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Intracellular Trafficking, Localization, and Mobilization of Platelet-Borne Thiol Isomerases

Marilena Crescente1, Fred G Pluthero1, Ling Li1

  • 1From the School of Biological Sciences, University of Reading, Reading, United Kingdom (M.C., M.P.S., L.M.H., S.L., M.S.A., S.V., I.M.J., J.M.G.); Program in Cell Biology, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada (F.G.P., L.L., R.W.L., W.H.A.K.); Departments of Paediatrics and Biochemistry, University of Toronto, Toronto, Ontario, Canada (R.W.L., W.H.A.K.); School of Physiology and Pharmacology, University of Bristol, Bristol, United Kingdom (T.G.W., A.W.P.); and Division of Hematology, Brigham and Women's Hospital, Department of Medicine, Harvard Medical School, Boston, MA (H.F.).

Arteriosclerosis, Thrombosis, and Vascular Biology
|April 16, 2016
PubMed
Summary

Thiol isomerases move to platelet surfaces via a unique pathway independent of secretory granules, requiring actin polymerization but not membrane fusion. This finding clarifies their role in platelet activation and thrombus formation.

Keywords:
blood plateletsmegakaryocytesmembrane fusionprotein disulfide isomerasessecretory vesicles

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