Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Next-generation Sequencing

Next-generation Sequencing

The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features....

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

LiraSearch-ultrafast ligand shape and electrostatic matching server.

Bioinformatics advances·2026

Same author

Single-cell co-mapping reveals relationship between chromatin state and gene expression in early zebrafish development.

eLife·2026

Same author

Mast cell homeostasis depends on KIT ligand from dermal fibroblasts and perivascular cells in mouse skin.

The Journal of investigative dermatology·2026

Same author

The H3K36me3 methyltransferase SETD2 contributes to PAF1C interactions with RNA Pol II and is required for neuronal differentiation.

The EMBO journal·2026

Same author

Liver-derived Indian hedgehog (Ihh) couples fast-feed transition to thermogenic and metabolic homeostasis.

Molecular metabolism·2026

Same author

Lack of MDA5 delays hematopoietic aging by modulating inflammaging and proteostasis in mice.

Nature communications·2026

Same journal

Correction to 'New origin firing is inhibited by APC/CCdh1 activation in S-phase after severe replication stress'.

Nucleic acids research·2026

Same journal

VeloRM: disentangling pre- and post-splicing RNA modification dynamics at single-cell resolution.

Nucleic acids research·2026

Same journal

Accessibility of telomeric overhangs to stabilizing small-molecule ligands.

Nucleic acids research·2026

Same journal

Multivalent interactions mediate SNAIL transcription factor stimulation of the nucleosome deacetylase activity of the CoREST complex.

Nucleic acids research·2026

Same journal

Genome-wide mapping of DNA G-quadruplexes in Trypanosoma brucei chromatin reveals enrichment in coding regions and transcription start sites.

Nucleic acids research·2026

Same journal

Correction to 'The Gene Ontology knowledgebase in 2026'.

Nucleic acids research·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Mar 22, 2026

Informatic Analysis of Sequence Data from Batch Yeast 2-Hybrid Screens

Informatic Analysis of Sequence Data from Batch Yeast 2-Hybrid Screens

Published on: June 28, 2018

deepTools2: a next generation web server for deep-sequencing data analysis.

Fidel Ramírez¹, Devon P Ryan¹, Björn Grüning²

¹Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany.

Nucleic Acids Research

|April 16, 2016

Summary

This summary is machine-generated.

The deepTools2 web server offers enhanced bioinformatics workflows for processing and visualizing deep sequencing data. This update improves data interpretation with new tools and features, accessible via web service or command line.

More Related Videos

Author Spotlight: Investigating the Role of Repetitive DNA Misregulation in Cancer Initiation and Immunotherapy Resistance

Author Spotlight: Investigating the Role of Repetitive DNA Misregulation in Cancer Initiation and Immunotherapy Resistance

Published on: December 13, 2024

A Bioinformatics Pipeline for Investigating Molecular Evolution and Gene Expression using RNA-seq

A Bioinformatics Pipeline for Investigating Molecular Evolution and Gene Expression using RNA-seq

Published on: May 28, 2021

Related Experiment Videos

Last Updated: Mar 22, 2026

Informatic Analysis of Sequence Data from Batch Yeast 2-Hybrid Screens

Informatic Analysis of Sequence Data from Batch Yeast 2-Hybrid Screens

Published on: June 28, 2018

Author Spotlight: Investigating the Role of Repetitive DNA Misregulation in Cancer Initiation and Immunotherapy Resistance

Author Spotlight: Investigating the Role of Repetitive DNA Misregulation in Cancer Initiation and Immunotherapy Resistance

Published on: December 13, 2024

A Bioinformatics Pipeline for Investigating Molecular Evolution and Gene Expression using RNA-seq

A Bioinformatics Pipeline for Investigating Molecular Evolution and Gene Expression using RNA-seq

Published on: May 28, 2021

Area of Science:

Bioinformatics
Genomics
Computational Biology

Background:

The deepTools Galaxy server, first introduced in 2014, provides a platform for processing and visualizing deeply sequenced data.
The core toolset, deepTools, enables comprehensive bioinformatics workflows from quality control to integrative analyses.

Purpose of the Study:

To present significant enhancements and new tools for the deepTools Galaxy server, improving data visualization and interpretation.
To provide an updated, accessible web service and deployable suite for deep sequencing data analysis.

Main Methods:

Development and integration of new tools and features within the deepTools suite.
Enhancement of existing functionalities for quality control, normalization, clustering, and visualization of sequencing data.
Provision of the deepTools2 suite for deployment in Galaxy frameworks and command-line usage.

Main Results:

Introduction of an updated deepTools2 suite with improved data visualization and interpretation capabilities.
Enhanced ability to perform complete bioinformatics workflows, including advanced integrative analyses.
Availability of a public API for programmatic access to deepTools functionality.

Conclusions:

The updated deepTools2 suite offers a powerful and flexible solution for analyzing deeply sequenced data.
The enhanced web server and tools are freely available, promoting wider accessibility and use in genomic research.
Continued community-driven development ensures deepTools remains a valuable resource for bioinformatics analyses.