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3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
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Update on New Daily Persistent Headache.

Hida Nierenburg1, Lawrence C Newman2

  • 1Mount Sinai West Hospital Center, The Headache Institute, 424 West 59th St. Suite 4A, New York, NY, 10019, USA.

Current Treatment Options in Neurology
|April 16, 2016
PubMed
Summary
This summary is machine-generated.

New daily persistent headache (NDPH) is a rare primary headache disorder often mistaken for migraine. While some cases resolve spontaneously, many persist, with limited effective treatments currently available.

Keywords:
DoxycyclineInternational classification of headache disordersNerve blockadeNew daily persistent headacheOnabotulinum toxin ATreatment

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Area of Science:

  • Neurology
  • Headache Medicine

Background:

  • New daily persistent headache (NDPH) is an uncommon primary headache disorder.
  • It can be clinically similar to migraine or tension-type headaches.
  • A key feature is the ability of most patients to identify the exact onset date, often following a viral illness.

Purpose of the Study:

  • To review the clinical characteristics, diagnosis, and treatment of New daily persistent headache (NDPH).
  • To highlight the challenges in managing this under-recognized headache disorder.

Main Methods:

  • Review of existing literature and clinical observations regarding NDPH.
  • Discussion of diagnostic criteria, including the exclusion of secondary headache causes.
  • Exploration of current and investigational therapeutic approaches.

Main Results:

  • NDPH presents with two temporal profiles: self-limited and persistent.
  • Diagnosis requires ruling out secondary causes through imaging and lab studies.
  • Most current treatments are partially effective, and medication overuse is common.

Conclusions:

  • Effective treatments for NDPH are limited, necessitating further research.
  • Investigational therapies like doxycycline/montelukast combinations and onabotulinum toxin show potential.
  • Accurate diagnosis and management of medication overuse are crucial.