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LIGHT May Improve Immune Checkpoint Blockade Response

    Cancer Discovery
    |April 16, 2016
    PubMed

    A new study suggests that insufficient T-cell infiltration may explain why a majority of patients do not respond to immunotherapy. Combining PD-L1 inhibitors with antibody-guided LIGHT, a protein that recruits tumor-infiltrating lymphocytes, increased antitumor response in mice, and may have the potential to improve patient response rates to immunotherapy.

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