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Updated: Mar 22, 2026

Author Spotlight: Enhancing Understanding and Treatment Strategies with the NEC-on-a-Chip Model
Published on: July 28, 2023
Intestinal failure following necrotizing enterocolitis: A clinical approach
Kelsey D J Jones1, Lucy J Howarth1
1Department of Paediatric Gastroenterology and Nutrition, Oxford Childrens' Hospital, Oxford University Hospitals NHS Foundation Trust, United Kingdom.
Necrotizing enterocolitis (NEC) can cause intestinal failure, but remaining bowel often adapts, allowing children to achieve enteral autonomy. Multidisciplinary care post-surgery is crucial for long-term success in managing these complications.
Area of Science:
- Pediatric surgery
- Gastroenterology
- Neonatal care
Background:
- Intestinal failure is a known complication following surgical management of necrotizing enterocolitis (NEC).
- Despite intestinal resection, functional adaptation of the remaining bowel allows many children to achieve enteral autonomy.
- Early, integrated multidisciplinary care is vital for successful long-term outcomes.
Purpose of the Study:
- To review the clinical approach for managing intestinal and nutritional complications in children after NEC surgery.
- To provide guidance on optimizing care for pediatric patients with surgical NEC.
Main Methods:
- Literature review focusing on clinical management strategies.
- Synthesis of evidence regarding post-operative care for NEC survivors.
- Discussion of multidisciplinary team roles in patient recovery.
Main Results:
- Children with surgically-managed NEC can achieve enteral autonomy through bowel adaptation.
- Integrated care models improve long-term outcomes for these patients.
- Specific strategies exist for managing intestinal and nutritional sequelae.
Conclusions:
- A comprehensive, multidisciplinary approach is essential for managing children with intestinal failure post-NEC.
- Early intervention and ongoing support facilitate functional recovery and enteral independence.
- This review outlines a framework for optimizing care pathways.
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