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Hypercalciuria in children with diabetes mellitus
Helvetica Paediatrica Acta
|February 1, 1989
Insights
Diabetic children may face kidney damage risk from high urinary calcium. About a quarter of these children exhibit hypercalciuria, a condition of excessive calcium in urine, without signs of kidney disease.
Area of Science:
- Pediatric Endocrinology
- Nephrology
- Metabolic Disorders
Background:
- Diabetic children are susceptible to various complications.
- Hypercalciuria is a potential risk factor for renal damage.
Purpose of the Study:
- To investigate the prevalence of hypercalciuria in diabetic children without nephropathy.
- To explore potential correlations between urinary calcium excretion and glycemic control.
Main Methods:
- Assessed urinary calcium excretion in 75 diabetic children without nephropathy.
- Analyzed diurnal variation and correlations with glucose excretion and HbA1c levels.
Main Results:
- 17 out of 75 (approximately 23%) diabetic children showed urinary calcium excretion exceeding 4 mg/kg/day.
- No significant diurnal variation in calciuria was observed.
- No correlation was found between calcium excretion and glucose excretion or HbA1c levels.
Conclusions:
- A notable proportion of diabetic children without nephropathy exhibit hypercalciuria.
- These children may be at increased risk for renal damage due to elevated calcium excretion.
- Further monitoring of urinary calcium is recommended for diabetic children.
Abstract:
Seventeen of 75 diabetic children without nephropathy had urinary calcium excretion of more than 4 mg/kg/day. Neither diurnal variation in calciuria, nor correlations between calcium excretion and glucose excretion as well as HbA1 levels were observed. The findings suggest that about one quarter of diabetic children is at risk for hypercalciuria and may be for renal damage due to hyperexcretion of calcium.