Related Experiment Video
Updated: Mar 22, 2026
09:34
Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells
Published on: February 9, 2019
9.6K
Lipid-based nanocarriers for oral peptide delivery
Zhigao Niu1, Inmaculada Conejos-Sánchez1, Brendan T Griffin2
1CIMUS Research Institute, University of Santiago de Compostela, Santiago de Compostela, Spain.
Advanced Drug Delivery Reviews
|April 16, 2016
Summary
Lipid-based nanostructures show promise for oral peptide and protein delivery. Their properties significantly influence gastrointestinal interactions and drug efficacy, guiding future development for commercial success.
Area of Science:
- Biomedical Engineering
- Pharmaceutics
- Drug Delivery
Background:
- Oral administration of peptides and proteins is challenging due to enzymatic degradation and poor absorption.
- Lipid-based nanostructures offer a potential solution for protecting and delivering these biologics.
- Understanding nanocarrier properties is crucial for effective oral delivery.
Purpose of the Study:
- To review lipid-based nanostructures for oral peptide and protein delivery.
- To analyze how nanocarrier properties affect gastrointestinal interactions and pharmacokinetic/pharmacodynamic (PK/PD) profiles.
- To identify key factors for successful oral nanocarrier-based drug delivery.
Main Methods:
- Literature review of lipid-based nanostructures for oral peptide/protein delivery.
- Analysis of physicochemical properties (particle size, zeta potential) and pharmaceutical properties (drug loading, release).
- Evaluation of nanocarrier interactions with the gastrointestinal environment and impact on PK/PD.
Main Results:
- Nanocarrier composition and properties critically influence oral bioavailability.
- Particle size, zeta potential, drug loading, and release kinetics affect gastrointestinal stability and absorption.
- Successful nanocarriers demonstrate optimized interactions with the GI tract.
Conclusions:
- Lipid-based nanostructures are viable for oral peptide/protein delivery.
- Careful optimization of nanocarrier properties is essential for therapeutic success.
- Addressing challenges in formulation and manufacturing is key for commercialization.
Related Concept Videos
01:24Site-Targeted Drug Delivery Systems: Polymeric Carriers
104
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
104
01:27Bioavailability Enhancement: Drug Permeability Enhancement
299
After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...
299
01:23Oral Drug Delivery Systems: Introduction
205
Oral drug delivery is the most common route of administration due to its convenience, cost-effectiveness, and high patient compliance. It enables precise formulation to ensure proper drug dosage and bioavailability. The development of oral dosage forms considers drug properties such as solubility, stability, and absorption to optimize therapeutic efficacy.Tablets, capsules, liquids, and chewable formulations enhance drug stability, mask undesirable tastes, and improve patient experience.
205
01:11Oral Drug Delivery Systems: Delayed-Release Systems
125
Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...
125
01:24Modified-Release Drug Delivery Systems: Site-Targeted
91
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
91
01:26Oral Drug Delivery Systems: Continuous-Release Systems
187
Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...
187