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Related Concept Videos

Elastin is Responsible for Tissue Elasticity01:12

Elastin is Responsible for Tissue Elasticity

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Elastic fiber contains the protein elastin along with lesser amounts of other proteins and glycoproteins. The main property of elastin is that it will return to its original shape after being stretched or compressed. Elastic fibers are prominent in elastic tissues found in skin and the elastic ligaments of the vertebral column.
Ligaments and tendons are made of dense regular connective tissue, but in ligaments not all fibers are parallel. Dense regular elastic tissue contains elastin fibers and...
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The Tumor Microenvironment02:17

The Tumor Microenvironment

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Introduction to Fibroblasts01:09

Introduction to Fibroblasts

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Rudolph Virchow discovered spindle-shaped cells called fibroblasts in 1858. Inactive fibroblasts, called fibrocytes, become activated by various stimuli, such as growth factors and inflammatory cytokines. Activated fibroblasts play a crucial role in wound healing, inflammation, formation of new blood vessels, and cancer progression. Uncontrolled activation of fibroblasts results in fibrosis, the excess deposition of fibrous tissue, which can lead to scarring and affect normal organs. This...
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Fibrous Proteins00:55

Fibrous Proteins

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Fibrous proteins are either long and narrow proteins or assemble to form long and thin structures. They contain repetitive units and usually consist of either alpha helices or beta sheets and, in rare cases, a mix of both. The amino acids in the primary structure often consist of repeating amino acid sequences. The role of fibrous proteins is primarily structural. Many are located in the extracellular matrix and are present in connective tissues to impart strength and joint mobility. They are...
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Papillary Dermis01:11

Papillary Dermis

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Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
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Fibril-associated Collagen01:11

Fibril-associated Collagen

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Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated collagens interrupted triple-helices). FACIT help connect and attach the collagen fibrils with each other as well as with other proteins of the extracellular matrix.
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
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Related Experiment Video

Updated: Mar 22, 2026

Fibroblast-Derived 3D Matrix System Applicable to Endothelial Tube Formation Assay
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Elastofibroma: An Uncommon Tumor Revisited.

Rashmi Patnayak1, Amitabh Jena2, Sarla Settipalli3

  • 1Department of Pathology, Sri Venkateswara Institute of Medical Sciences, Tirupati, Andhra Pradesh, India.

Journal of Cutaneous and Aesthetic Surgery
|April 16, 2016
PubMed
Summary

Elastofibromas are rare, slow-growing benign soft-tissue tumors. Accurate histopathology diagnosis is crucial to avoid unnecessary surgical resection for these tumors.

Keywords:
Elastic fibersVerhoeff's stainelastofibromasoft-tissue

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Area of Science:

  • Oncology
  • Pathology
  • Dermatology

Background:

  • Elastofibromas are rare, benign soft-tissue tumors.
  • They predominantly affect elderly females and commonly occur in the infrascapular region.
  • Surgical resection is typically reserved for symptomatic cases.

Observation:

  • A case of elastofibroma in a 46-year-old female is presented, featuring a gradually increasing soft-tissue swelling.
  • The mass, measuring 8 cm × 6 cm, was located in the right inferior subscapular region over a 2-year period.
  • Microscopic examination revealed characteristic eosinophilic, beaded elastic fibers, confirmed by Verhoeff's elastic stain.

Findings:

  • Histopathological examination confirmed the diagnosis of elastofibroma.
  • The presence of characteristic beaded elastic fibers is a key diagnostic feature.
  • Accurate histopathological diagnosis is essential for appropriate patient management.

Implications:

  • This case underscores the importance of histopathology in diagnosing elastofibromas.
  • A definitive diagnosis can prevent unnecessary wide and radical surgical resections.
  • Accurate diagnosis ensures conservative management for benign conditions like elastofibroma.