FGF23 as a calciotropic hormone
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Updated: Mar 22, 2026

Imaging Calcium Dynamics in Subpopulations of Mouse Pancreatic Islet Cells
Published on: November 26, 2019
María E Rodríguez-Ortiz1, Mariano Rodríguez2
1Laboratory of Nephrology, IIS-Fundación Jiménez Díaz, Madrid, Spain, 28040, Spain.
Abstract:
Maintaining mineral metabolism requires several organs and hormones. Fibroblast growth factor 23 (FGF23) is a phosphatonin produced by bone cells that reduces renal production of calcitriol - 1,25(OH) 2D 3 - and induces phosphaturia. The consequences of a reduction in 1,25(OH) 2D 3 involve changes in calcium homeostasis. There are several factors that regulate FGF23: phosphorus, vitamin D, and parathyroid hormone (PTH). More recently, several studies have demonstrated that calcium also modulates FGF23 production. In a situation of calcium deficiency, the presence of 1,25(OH) 2D 3 is necessary to optimize intestinal absorption of calcium, and FGF23 is decreased to avoid a reduction in 1,25(OH) 2D 3 levels.
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