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First case of vanA-positive Enterococcus mundtii in human urinary tract infection in Iran

M Sharifi-Rad1, S Shadanpour2, A van Belkum3

  • 1Zabol University of Medical Sciences, Iran.

New Microbes and New Infections
|April 16, 2016
PubMed

Insights

This study identified seven Enterococcus species in Iranian urinary tract infections. While vancomycin resistance was low overall (3.9%), the first vanA-positive Enterococcus mundtii UTI was found.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Clinical Diagnostics

Background:

  • Enterococci are significant pathogens causing urinary tract infections (UTIs).
  • Vancomycin resistance in enterococci is a growing global health concern.
  • Surveillance of enterococcal species and antimicrobial resistance is crucial for effective treatment.

Observation:

  • Enterococci were cultured from UTIs in Iranian hospitals.
  • Seven distinct Enterococcus species were identified: E. raffinosus, E. durans, E. hirae, E. avium, E. mundtii, E. faecium, and E. faecalis.
  • A low overall vancomycin resistance rate of 3.9% was observed.

Findings:

  • Seven vancomycin-resistant enterococci (VRE) strains were detected.
  • This study reports the first isolation of vanA-positive Enterococcus mundtii causing UTIs.
  • Enterococcal infection rates were high, but the incidence of VRE was low.

Implications:

  • The emergence of vanA-positive E. mundtii highlights the need for ongoing monitoring of antimicrobial resistance.
  • Understanding the species distribution and resistance patterns of enterococci is vital for guiding empirical antibiotic therapy in UTIs.
  • This finding contributes to the global understanding of VRE epidemiology and the potential for novel resistance mechanisms.
Keywords:
E. mundtiiEnterococcal infectionVancomycin-resistant enterococciurinary tract infectionvanA-positive

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