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Updated: Mar 22, 2026

Characterization of Glycoproteins with the Immunoglobulin Fold by X-Ray Crystallography and Biophysical Techniques
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Humanin: Functional Interfaces with IGF-I.

J Xiao1, S-J Kim1, P Cohen1

  • 1Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA.

Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society
|April 16, 2016
PubMed
Summary
This summary is machine-generated.

Humanin, a novel mitochondrial peptide, shows neuroprotective benefits in various diseases. It interacts with Insulin-like Growth Factor-I (IGF-I) signaling pathways, suggesting a new role in cellular regulation.

Keywords:
Growth hormoneHumaninIGF-IMitochondriaNeuroprotectionPeptide

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Area of Science:

  • Mitochondrial biology
  • Endocrinology
  • Neuroscience

Background:

  • Humanin is a recently discovered peptide encoded by the mitochondrial genome.
  • It is the first of a new class of mitochondrial-derived peptides.
  • Humanin exhibits neuroprotective effects and benefits in models of stroke, cardiovascular disease, and cancer.

Purpose of the Study:

  • To review the known interactions between humanin and Insulin-like Growth Factor-I (IGF-I).
  • To highlight humanin's role in IGF-I signaling.

Main Methods:

  • Literature review of studies on humanin and IGF-I.
  • Analysis of experimental data on humanin-IGF-I binding and regulation.

Main Results:

  • Humanin binds to IGF-binding protein 3 (IGFBP-3).
  • Humanin decreases circulating IGF-I levels.
  • IGF-I appears to regulate humanin levels.

Conclusions:

  • Humanin is a significant factor in IGF-I signaling.
  • The precise mechanisms of humanin-IGF-I cross-regulation require further elucidation.