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Updated: Mar 22, 2026

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SLC22A1/OCT1 Genotype Affects O-desmethyltramadol Exposure in Newborn Infants

Maja Matic1, Saskia N de Wildt, Laure Elens

  • 1*Department of Clinical Chemistry, Erasmus University Medical Centre; Departments of †Intensive Care and ‡Paediatric Surgery, Sophia Children's Hospital, Erasmus University Medical Centre, Rotterdam, the Netherlands; §Integrated PharmacoMetrics, PharmacoGenomics and PharmacoKinetics, Louvain Drug Research Institute, Université Catholique de Louvain, Brussels; ¶Center for Clinical Pharmacology, University Hospitals Leuven & Department of Pharmaceutical and Pharmacological Sciences, University Hospitals; ‖Drug Delivery and Disposition, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven; and **Neonatal Intensive Care Unit, University Hospitals, Leuven, Belgium.

Therapeutic Drug Monitoring
|April 16, 2016
PubMed
Summary

The organic cation transporter 1 (OCT1) genotype influences tramadol metabolism in infants. Genetic variations in SLC22A1, encoding OCT1, affect O-desmethyltramadol (M1) levels, impacting drug response in neonates.

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