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Adaptive Mechanisms in Cancer Cells02:53

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Updated: Mar 22, 2026

Artificial Antigen Presenting Cell aAPC Mediated Activation and Expansion of Natural Killer T Cells
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Apelin/APJ system and cancer.

Yanjie Yang1, Shuang-Yu Lv1, Wenling Ye1

  • 1School of Medicine, Henan University, Kaifeng, Henan 475004, China.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|April 17, 2016
PubMed
Summary

The apelin/apelin receptor (APJ) system, found in many organs, plays a role in various cancers. This system shows potential as an anticancer therapeutic target.

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APJApelinCancerCarcinomaVessels

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • The apelin/apelin receptor (APJ) system is a signaling pathway with widespread tissue distribution.
  • It plays crucial roles in cardiovascular and vascular functions, including development and cell proliferation.

Purpose of the Study:

  • To summarize the role of the apelin/APJ system in various cancers.
  • To explore its potential as an anticancer therapeutic target.

Main Methods:

  • Literature review of studies investigating the apelin/APJ system in cancer.
  • Analysis of the system's involvement in tumor neoangiogenesis.

Main Results:

  • The apelin/APJ system is implicated in lung, gastroesophageal, colonic, liver, prostate, endometrial, oral squamous cell, and brain cancers.
  • It also influences tumor neoangiogenesis.

Conclusions:

  • The apelin/APJ system is a significant factor in the development and progression of multiple cancer types.
  • Targeting the apelin/APJ system presents a promising strategy for cancer therapy.