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Updated: Mar 22, 2026

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Bioprinting of Hydrogel Tumor Slices as a 3D Model for Mantle Cell Lymphoma
Published on: September 12, 2025
990
Clinical Management Updates in Mantle Cell Lymphoma
Oncology (Williston Park, N.Y.)
|April 17, 2016
Summary
Mantle cell lymphoma, an aggressive non-Hodgkin lymphoma, is becoming more treatable. Advances in targeted therapies and maintenance strategies are improving patient survival rates.
Area of Science:
- Hematology
- Oncology
- Immunology
Background:
- Mantle cell lymphoma (MCL) is an aggressive B-cell non-Hodgkin lymphoma often presenting with a poor prognosis.
- Current risk stratification relies on clinical and biological biomarkers.
- Optimal induction therapy has been informed by randomized trials since 2015.
Purpose of the Study:
- To review recent advances in the management of mantle cell lymphoma.
- To highlight novel therapeutic targets and treatment strategies for relapsed/refractory disease.
- To discuss the role of minimal residual disease monitoring and maintenance therapy.
Main Methods:
- Review of recent clinical trials and translational research findings.
- Analysis of novel therapeutic pathways and agents.
- Evaluation of minimal residual disease monitoring and maintenance strategies.
Main Results:
- Identification of new molecular targets for therapeutic intervention.
- Development of novel agents for relapsed/refractory mantle cell lymphoma.
- Improved outcomes with minimal residual disease-guided maintenance therapy post-induction or post-stem cell transplantation.
Conclusions:
- Significant progress has been made in treating mantle cell lymphoma.
- Translational and clinical research efforts have improved overall survival.
- Continued research promises further improvements in patient outcomes.
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