Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Translesion DNA Polymerases02:10

Translesion DNA Polymerases

11.6K
Translesion (TLS) polymerases rescue stalled DNA polymerases at sites of damaged bases by replacing the replicative polymerase and installing a nucleotide across the damaged site. Doing so, TLS allows additional time for the cell to repair the damage before resuming regular DNA replication.
TLS polymerases are found in all three domains of life - archaea, bacteria, and eukaryotes. Of the different classes of TLS polymerases, members of the Y family are fitted with specialized structures that...
11.6K
Coordination of Gene Expression Processes in Bacteria01:29

Coordination of Gene Expression Processes in Bacteria

849
The DNA replication, transcription, and translation processes are intricately coupled in bacteria, allowing efficient gene expression and rapid protein synthesis. While this physical and functional coordination is advantageous, it introduces challenges that bacteria overcome through specific regulatory mechanisms.Coupling of Replication, Transcription, and TranslationThe coupling of replication, transcription, and translation is a hallmark of bacterial gene expression. As the replisome unwinds...
849
Actin Polymerization01:42

Actin Polymerization

8.9K
Actin polymerization occurs through the head-to-tail association of binding sites on monomeric actin or G-actin to form filamentous or F-actin. The polymerization can be divided into three phases ̶  nucleation, elongation, and steady-state phase.
The nucleation phase involves forming a stable nucleus consisting of three actin monomers to form a new actin filament. Actin-binding proteins such as formins and Arp2/3 complex help filament growth post-nucleation. The Formins form straight...
8.9K
Post-translational Translocation of Proteins to the RER01:27

Post-translational Translocation of Proteins to the RER

8.0K
A sizable fraction of proteins destined for ER are first synthesized in the cell cytosol and then transported across the ER membrane–a process called post-translational translocation. Similar to cotranslationally translocated proteins, these proteins also use the Sec translocon complex to enter the ER lumen.
Targeting proteins to the ER
Hsp40 and Hsp70 chaperone molecules bind the translated proteins in the cytosol to prevent their folding. The chaperone binding helps to keep the signal...
8.0K
Radical Chain-Growth Polymerization: Mechanism01:09

Radical Chain-Growth Polymerization: Mechanism

3.8K
The radical chain-growth polymerization mechanism consists of three steps: initiation, propagation, and termination of polymerization. The polymerization initiates when a free radical generated from the radical initiator adds to the unsaturated bond in the monomer. The unpaired electron of the free radical and one π electron in the unsaturated bond creates a σ bond between the free radical and the monomer. As a result, the other π electron in the unsaturated bond converts this species into...
3.8K
Cotranslational Protein Translocation01:20

Cotranslational Protein Translocation

10.9K
Translocation of proteins across membranes is an ancient process that occurs even in bacteria and archaebacteria. In fact, the components of the translocation machinery are still conserved between prokaryotes and eukaryotes.
Sec61 channel partners for cotranslational translocation
During cotranslational translocation, the Sec61 channel partners with the signal recognition particle (SRP), the signal recognition particle receptor (SR), and the ribosomes to transport the nascent polypeptide chain...
10.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evolutionary and Structural Insights into Proline Metabolism Genes Associated with Salt Resilience in Mango.

Biochemical genetics·2026
Same author

Metabolite-Mediated Antioxidant-Rich Bacterial Isolates for the Control of Anthracnose Disease and Enhancement of the Post-Harvest Shelf Life of Mango (<i>Mangifera indica</i> L.).

Plants (Basel, Switzerland)·2026
Same author

Turning Off the Powerhouse: Mitochondria-Targeted DPPZ-Ru(II)/Ir(III)/Re(I) Complexes Trigger Dual Mitophagy and Apoptosis To Halt Triple-Negative Breast Cancer.

Journal of medicinal chemistry·2026
Same author

Harnessing the Potential of a Secondary Metabolite-Based Formulation for the Post-Harvest Disease Management and Shelf Life Extension of Banana.

Metabolites·2026
Same author

Dual functioning Ru(II)/Ir(III) complexes for ferroptosis and apoptosis in triple-negative breast cancer: a proof of concept by glutathione depletion.

Dalton transactions (Cambridge, England : 2003)·2025
Same author

Global Optimization of the Control Strategy of a Brownian Information Engine: Efficient Information-Energy Exchange in a Generalized Potential Energy Surface.

The journal of physical chemistry. A·2025
Same journal

Revisiting crossed-correlated baths in open quantum systems simulated by HEOM or T-TEDOPA.

The Journal of chemical physics·2026
Same journal

Vesicle size and membrane composition control monomer transfer pathways in multicomponent lipid vesicles.

The Journal of chemical physics·2026
Same journal

Polaron-mediated exciton dynamics of P(NDI2OD-T2) unveiled by transient absorption spectroscopy under electrochemical conditions.

The Journal of chemical physics·2026
Same journal

Green-Kubo relation in a mesoscale odd fluid model.

The Journal of chemical physics·2026
Same journal

Nitrogenation of microscopic MoS2 surfaces by oxidation scanning probe lithography.

The Journal of chemical physics·2026
Same journal

Molecular structure, binding, and disorder in TDBC-Ag plexcitonic assemblies.

The Journal of chemical physics·2026
See all related articles

Related Experiment Video

Updated: Mar 22, 2026

Optical Tweezers to Study RNA-Protein Interactions in Translation Regulation
12:26

Optical Tweezers to Study RNA-Protein Interactions in Translation Regulation

Published on: February 12, 2022

6.1K

Stochastic resonance during a polymer translocation process.

Debasish Mondal1, M Muthukumar1

  • 1Department of Polymer Science and Engineering, University of Massachusetts, Amherst, Massachusetts 01003, USA.

The Journal of Chemical Physics
|April 17, 2016
PubMed
Summary
This summary is machine-generated.

Stochastic resonance occurs during polymer translocation through nanopores only when an energy barrier is present. Chain entropy then dictates optimal synchronization conditions for this phenomenon.

More Related Videos

High-resolution Imaging and Analysis of Individual Astral Microtubule Dynamics in Budding Yeast
10:23

High-resolution Imaging and Analysis of Individual Astral Microtubule Dynamics in Budding Yeast

Published on: April 20, 2017

10.1K
Structure-Based Simulation and Sampling of Transcription Factor Protein Movements along DNA from Atomic-Scale Stepping to Coarse-Grained Diffusion
09:17

Structure-Based Simulation and Sampling of Transcription Factor Protein Movements along DNA from Atomic-Scale Stepping to Coarse-Grained Diffusion

Published on: March 1, 2022

3.6K

Related Experiment Videos

Last Updated: Mar 22, 2026

Optical Tweezers to Study RNA-Protein Interactions in Translation Regulation
12:26

Optical Tweezers to Study RNA-Protein Interactions in Translation Regulation

Published on: February 12, 2022

6.1K
High-resolution Imaging and Analysis of Individual Astral Microtubule Dynamics in Budding Yeast
10:23

High-resolution Imaging and Analysis of Individual Astral Microtubule Dynamics in Budding Yeast

Published on: April 20, 2017

10.1K
Structure-Based Simulation and Sampling of Transcription Factor Protein Movements along DNA from Atomic-Scale Stepping to Coarse-Grained Diffusion
09:17

Structure-Based Simulation and Sampling of Transcription Factor Protein Movements along DNA from Atomic-Scale Stepping to Coarse-Grained Diffusion

Published on: March 1, 2022

3.6K

Area of Science:

  • Soft matter physics
  • Polymer physics
  • Statistical mechanics

Background:

  • Polymer translocation through nanopores is crucial for biological processes and nanotechnology.
  • Stochastic resonance is a phenomenon where a weak signal can be amplified by noise, enhancing system performance.
  • Understanding the factors influencing polymer translocation dynamics is essential for controlling nanoscale processes.

Purpose of the Study:

  • To investigate the occurrence and conditions for stochastic resonance during single-file polymer translocation through a nanopore.
  • To determine the role of free energy barriers, driving forces, and polymer properties in enabling stochastic resonance.
  • To derive analytical criteria for the emergence of stochastic resonance in this system.

Main Methods:

  • Combining the Fokker-Planck formalism for polymer translocation with a two-state model for stochastic resonance.
  • Deriving analytical formulas for the conditions of stochastic resonance.
  • Analyzing the influence of chain length, pore length, polymer-pore interactions, and cavity confinement on translocation dynamics.

Main Results:

  • Stochastic resonance is not possible if the free energy barrier is purely entropic.
  • The polymer chain exhibits stochastic resonance only when an energy threshold, related to polymer-pore interactions, is present.
  • Once stochastic resonance is feasible, polymer chain entropy significantly influences the optimal synchronization conditions.

Conclusions:

  • The presence of an energy barrier is a prerequisite for stochastic resonance in polymer translocation through nanopores.
  • Polymer-pore interactions play a critical role in enabling stochastic resonance.
  • Chain entropy is a key factor in optimizing the synchronization conditions for stochastic resonance during translocation.