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Author Spotlight: Advancements and Challenges in Hepatitis B Virus Detection
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Author Spotlight: Advancements and Challenges in Hepatitis B Virus Detection

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Chronic Hepatitis B Is Associated with Higher Inpatient Resource Utilization and Mortality Versus Chronic Hepatitis C

George Cholankeril1, Ryan B Perumpail2, Menghan Hu3

  • 1Department of Internal Medicine, Roger Williams Medical Center, Boston University School of Medicine, 825 Chalkstone Avenue, Providence, RI, 02908, USA. gcholankeril@gmail.com.

Digestive Diseases and Sciences
|April 17, 2016
PubMed

Insights

Chronic hepatitis B (HBV) and hepatitis C (HCV) infections cause significant inpatient costs and resource use. HBV hospitalizations show higher mortality and longer stays than HCV, highlighting the need for early HBV diagnosis and care.

Area of Science:

  • Hepatology
  • Infectious Diseases
  • Health Economics

Background:

  • Chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) are major causes of chronic liver disease and liver cancer.
  • Current healthcare initiatives aim for early diagnosis and linkage to care to reduce costs associated with advanced liver disease.

Purpose of the Study:

  • To evaluate the impact of liver complications from chronic HBV and HCV on inpatient costs, length of stay, and mortality.
  • To compare resource utilization between HBV and HCV related hospitalizations.

Main Methods:

  • Utilized the Healthcare Cost and Utilization Project, National Inpatient Sample (HCUP-NIS) database.
  • Analyzed inpatient data from 2003 to 2012 for adult patients in the USA.
  • Compared HBV and HCV related hospitalizations regarding cost, length of stay, and mortality.

Main Results:

  • HBV infections accounted for 0.18% and HCV for 1.36% of all hospitalizations studied.
  • HBV hospitalizations had higher inpatient mortality (OR 1.34), increased median cost (+$2100.33), and longer stays (+0.64 days) compared to HCV.
  • p < 0.01 for increased length of stay.

Conclusions:

  • Despite higher per-case resource utilization, HBV patients exhibit lower inpatient survival than HCV patients.
  • These findings emphasize the critical need for early diagnosis of chronic HBV infection in at-risk populations.
  • Prompt linkage to care for HBV is essential to improve outcomes and manage healthcare costs.
Abstract

Keywords:
Chronic hepatitis BChronic hepatitis CHealthcare utilizationLinkage to care

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