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Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease
04:41

Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease

Published on: July 3, 2018

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MicroRNAs as circulating biomarkers in acute coronary syndromes: A review

Fredrik Ahlin1, John Arfvidsson1, Kris G Vargas2

  • 13rd Department of Medicine, Cardiology and Intensive Care Medicine, Wilhelminen hospital, Vienna, Austria; Faculty of Medicine and Health Sciences, Linköping University, Linköping, Sweden.

Vascular Pharmacology
|April 17, 2016
PubMed

Insights

MicroRNAs (miRNAs) show promise as novel biomarkers for diagnosing myocardial infarction (MI), potentially improving emergency department patient care beyond current cardiac troponin (cTn) tests for coronary artery disease (CAD).

Area of Science:

  • Biomarkers and Diagnostics
  • Cardiovascular Disease Research

Background:

  • Coronary artery disease (CAD) is a leading global cause of mortality.
  • Current diagnosis of myocardial infarction (MI) relies on cardiac troponins (cTn), but new biomarkers are needed for improved accuracy.
  • MicroRNAs (miRNAs) have emerged as potential diagnostic markers across various diseases.

Purpose of the Study:

  • To review recent studies on microRNAs (miRNAs) as diagnostic biomarkers for myocardial infarction (MI).
  • To discuss the potential clinical utility of miRNAs in MI diagnosis and risk stratification.

Main Methods:

  • Literature review of prominent studies investigating miRNAs in MI.
  • Analysis of the diagnostic and prognostic value of miRNAs in the context of MI.

Main Results:

  • Selected studies highlight specific miRNAs with altered expression levels in MI patients.
  • miRNAs demonstrate potential for early and accurate MI detection, complementing existing biomarkers.
  • Further research is needed to validate miRNA performance in diverse clinical settings.

Conclusions:

  • MicroRNAs represent a promising class of novel biomarkers for myocardial infarction (MI) diagnosis.
  • Integrating miRNA analysis may enhance the diagnostic and risk-stratification capabilities for MI patients.
  • Continued investigation is crucial to establish miRNAs as reliable tools in clinical practice.

Keywords:
Acute coronary syndromeBiomarkerMicroRNATroponin

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