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Maternal Inflammatory Bowel Disease During Pregnancy is Not a Risk Factor for Long-term Morbidity of the Offspring
Amir Freud1, Ofer Beharier1, Asnat Walfisch1
1Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Insights
Children born to mothers with inflammatory bowel disease [IBD] during pregnancy do not face a higher risk of long-term childhood illnesses. This study found no increased paediatric morbidity in offspring of mothers with IBD.
Area of Science:
- Reproductive Medicine
- Paediatric Health
- Gastroenterology
Background:
- Inflammatory bowel disease (IBD) affects women of reproductive age.
- Pregnancy in women with IBD requires careful monitoring for potential offspring health risks.
Purpose of the Study:
- To determine if maternal IBD during pregnancy increases the risk of long-term paediatric morbidity in offspring up to age 18.
- To investigate specific categories of long-term childhood diseases.
Main Methods:
- Population-based cohort study design.
- Inclusion of deliveries between 1991-2014 from a tertiary medical centre.
- Exclusion of newborns with congenital malformations and multiple pregnancies.
Main Results:
- A cohort of 255,352 deliveries was analyzed, with 278 offspring born to mothers with IBD.
- No statistically significant increased risk of long-term paediatric morbidity was observed in offspring of mothers with IBD.
- Specific morbidities analyzed included cardiovascular, endocrine, neurological, haematological, respiratory, gastrointestinal, and urinary conditions.
Conclusions:
- Maternal IBD during pregnancy is not identified as a risk factor for long-term paediatric morbidity.
- Offspring of mothers with IBD exhibit similar long-term health outcomes compared to the general population.
Background And Aims:
To investigate whether offspring of women suffering from inflammatory bowel disease [IBD] during their pregnancy are at an increased risk for long-term paediatric morbidity.
Methods:
In this population-based cohort study, we investigated the incidence of long-term [up to the age of 18 years] hospitalizations due to cardiovascular, endocrine, neurological, haematological, respiratory, gastrointestinal, and urinary paediatric morbidities of offspring of mothers affected by IBD during their pregnancy. Deliveries occurred between the years 1991 and 2014 in a regional tertiary medical centre. Newborns with congenital malformations as well as multiple pregnancies were excluded from the study.
Results:
During the study period, 255 352 deliveries met the inclusion criteria; 278 offspring were born to mothers with IBD. During the follow-up period, children born to mothers with IBD did not have an increased risk for long-term [up to the age of 18 years] morbidity compared with the control group.
Conclusion:
Maternal IBD during pregnancy is not a risk factor for long-term paediatric morbidity of the offspring.
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