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Quantifying Acute Changes in Renal Sympathetic Nerve Activity in Response to Central Nervous System Manipulations in Anesthetized Rats
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Neural modulation for hypertension and heart failure

S Smith1, P Rossignol2, S Willis1

  • 1The Ohio State University Wexner Medical Center, Department of Internal Medicine and Division of Cardiology, Columbus, OH, USA.

International Journal of Cardiology
|April 17, 2016
PubMed

Insights

Neuromodulation offers new hope for resistant hypertension and heart failure. Exploring therapies like renal denervation and vagal stimulation may improve outcomes when combined with existing treatments.

Area of Science:

  • Cardiovascular Medicine
  • Neurology
  • Medical Technology

Background:

  • Hypertension (HTN) and heart failure (HF) significantly increase global morbidity and mortality.
  • Sub-optimal HTN treatment elevates risks for stroke, renal failure, and HF.
  • Outcomes for HF patients remain poor despite current pharmacological and device therapies.

Purpose of the Study:

  • To review the evidence for neuromodulation in treating resistant HTN and HF.
  • To explore synergistic effects of neuromodulation with existing drug and device therapies.
  • To outline strategies for improving future neuromodulation trial success.

Main Methods:

  • Review of current evidence on neuromodulation techniques.
  • Analysis of neuromodulation in relation to established treatments (pharmacologic, CRT, ICDs).
  • Discussion of lessons learned from recent neuromodulation trials.

Main Results:

  • Neuromodulation, including renal denervation, baro-reflex modulation, and vagal stimulation, shows potential for resistant HTN and HF.
  • Potential for synergistic effects exists when combining neuromodulation with conventional therapies.
  • Insights gained from past trials can guide future research and improve success rates.

Conclusions:

  • Neuromodulation represents a promising frontier for managing treatment-resistant hypertension and heart failure.
  • Further research and optimized trial designs are crucial for realizing the full potential of these therapies.
  • Combining neuromodulation with existing treatments may offer enhanced therapeutic benefits for patients.

Keywords:
BaroreceptorHeart failureHypertensionNeural modulationRenal denervation

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