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Lysergic acid diethylamide (LSD) increases global brain connectivity, particularly in areas rich in serotonin 2A receptors. This expansion of brain network communication correlates with subjective experiences of ego dissolution.

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Area of Science:

  • Neuroscience
  • Psychopharmacology

Background:

  • Lysergic acid diethylamide (LSD) is a potent psychedelic with a history in psychiatric research.
  • Despite its historical use, modern human brain imaging studies on LSD's acute effects are lacking.

Purpose of the Study:

  • To investigate the acute effects of LSD on intrinsic functional connectivity in the human brain using fMRI.
  • To explore the relationship between LSD-induced brain changes and subjective experiences.

Main Methods:

  • Functional magnetic resonance imaging (fMRI) was employed to study brain activity.
  • Participants underwent fMRI scans while under the influence of LSD.

Main Results:

  • LSD increased global functional connectivity in high-level association cortices and the thalamus.
  • Increased connectivity areas significantly overlapped with serotonin 2A (5-HT2A) receptor density maps.
  • LSD promoted global brain integration, blurring boundaries between distinct neural networks and correlating with ego dissolution.

Conclusions:

  • LSD selectively expands global brain connectivity, disrupting the brain's modular and rich-club organization.
  • These findings provide the first neuroimaging evidence for LSD's effects on brain network integration and its link to altered self-perception.