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Coagulation disorders and their cutaneous presentations: Pathophysiology

Yunyoung Chang1, Ganary Dabiri2, Elizabeth Damstetter1

  • 1Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts.

Journal of the American Academy of Dermatology
|April 18, 2016
PubMed

Insights

Hypercoagulable states increase thrombosis risk. Dermatologists can identify these conditions through skin symptoms, improving patient outcomes by reducing related morbidity and mortality.

Area of Science:

  • Hematology
  • Dermatology
  • Pathophysiology

Background:

  • Hypercoagulable states are inherited or acquired conditions predisposing individuals to thrombosis.
  • Understanding these states involves analyzing the complex coagulation cascade.
  • Cutaneous manifestations can be early indicators of underlying hypercoagulable conditions.

Purpose of the Study:

  • To review the epidemiology and pathophysiology of hypercoagulable states.
  • To highlight the critical role of dermatologists in identifying and managing these conditions.
  • To provide a foundation for understanding clinical features, diagnostics, and treatment in the accompanying article.

Main Methods:

  • Literature review focusing on epidemiology and pathophysiology.
  • Analysis of the coagulation cascade in relation to thrombotic events.
  • Correlation of dermatological presentations with hypercoagulable states.

Main Results:

  • Hypercoagulable states represent a significant risk factor for both venous and arterial thromboses.
  • Early recognition of cutaneous symptoms by dermatologists can lead to timely diagnosis.
  • Understanding pathophysiology is key to comprehending the predisposition to clot formation.

Conclusions:

  • Dermatologists are pivotal in the early diagnosis and management of hypercoagulable states.
  • Identifying skin manifestations can significantly reduce patient morbidity and mortality.
  • This review provides essential epidemiological and pathophysiological context for hypercoagulable states.

Keywords:
antiphospholipid syndromeantithrombincoagulation cascadecryoglobulinemiafactor V Leidenhypercoagulable statehyperhomocysteinemiaprotein Cprotein Sprothrombinsickle cell disease

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