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Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
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Is Personalized Medicine Here?

Benedito A Carneiro, Ricardo Costa, Timothy Taxter

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    |April 18, 2016
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    Summary
    This summary is machine-generated.

    Genomic advances are revolutionizing personalized cancer treatment and drug development. Rigorous validation of molecular diagnostics is crucial for translating these discoveries into clinical practice.

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    Area of Science:

    • Oncology
    • Genomics
    • Molecular Diagnostics

    Background:

    • Technological advancements in genomics have enabled the identification of critical genetic alterations in cancer.
    • This has led to a paradigm shift towards personalized cancer treatment strategies.

    Purpose of the Study:

    • To review achievements in cancer therapeutics and molecular diagnostics.
    • To detail evolving molecular platforms for cancer treatment.
    • To highlight challenges in translating genomic discoveries into clinical practice.

    Main Methods:

    • Review of current literature on cancer genomics and personalized medicine.
    • Analysis of molecular diagnostic platforms, including whole-exome sequencing and patient-derived xenografts.
    • Discussion of drug development and clinical trial design in the context of cancer genomics.

    Main Results:

    • Genomic understanding is reshaping drug discovery and clinical trial design.
    • Validation of molecular diagnostics is critical for guiding treatment decisions.
    • Personalized oncology relies on the integration of genomic data into clinical practice.

    Conclusions:

    • Genomic insights have significantly advanced personalized cancer therapy.
    • Further validation and integration of molecular platforms are needed for widespread clinical adoption.
    • Translating genomic discoveries into daily clinical practice remains a key challenge.