Related Experiment Video

Updated: Mar 22, 2026

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
19:15

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Published on: August 25, 2014

88.4K

Population impact of preterm birth and low birth weight on developmental disabilities in US children

Laura A Schieve1, Lin H Tian1, Kristin Rankin2

  • 1National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA.

Annals of Epidemiology
|April 18, 2016
PubMed

Insights

Preterm birth significantly impacts child neurodevelopment, with varying effects across different developmental disabilities (DDs). Understanding these population impacts is crucial for public health initiatives.

Area of Science:

  • Neuroscience
  • Developmental Pediatrics
  • Public Health

Background:

  • Previous research indicates links between adverse perinatal outcomes and developmental disabilities (DDs).
  • However, the population-level impact of these associations remains understudied.
  • Understanding these impacts is vital for effective public health strategies and interventions.

Purpose of the Study:

  • To quantify the population attributable fractions (PAFs) for associations between birth weight categories and neurodevelopmental outcomes.
  • To assess the adjusted relative risks (aRRs) for various developmental disabilities in children aged 3-17 years.
  • To determine the population impact of preterm birth and/or low birth weight on specific neurodevelopmental conditions.

Main Methods:

  • Utilized data from the 2011-2012 National Survey of Children's Health.
  • Calculated adjusted relative risks (aRRs) for associations between birth weight (VLBW, MLBW, NBW) and preterm status with seven DDs.
  • Computed population attributable fractions (PAFs) to estimate the population-level impact of these risk factors.

Main Results:

  • Strong associations were found between preterm birth and cerebral palsy (CP), intellectual disability (ID), and autism spectrum disorder (ASD).
  • Population attributable fractions were highest for CP (55%), followed by ID, ASD, and learning disability (LD) (10%-20%).
  • Attention-deficit-hyperactivity disorder (ADHD) and behavioral-conduct disorders had a lower population impact (<5%).

Conclusions:

  • Preterm birth significantly influences child neurodevelopment across various conditions.
  • The relative associations and population impacts differ substantially depending on the specific developmental disability.
  • These findings underscore the importance of addressing perinatal factors to mitigate the burden of neurodevelopmental disorders.
Abstract

Keywords:
Developmental disabilitiesInfantLow birth weightPremature birthRisk factor

More Related Videos

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats07:36

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

12.0K
Author Spotlight: Collecting the Brain and Serum from the Same Mice Fetus to Study Brain Tumor Development05:44

Author Spotlight: Collecting the Brain and Serum from the Same Mice Fetus to Study Brain Tumor Development

Published on: May 17, 2024

1.2K

Related Concept Videos

Intellectual Disability01:29

Intellectual Disability

Intellectual disability (ID) is a neurodevelopmental condition characterized by deficits in intellectual and adaptive functioning that manifest during the developmental period. This condition encompasses challenges in reasoning, memory, problem-solving, and learning, accompanied by impairments in everyday life skills, such as communication, self-care, and social interactions. Intellectual disability affects approximately 1% of the population in the United States, impacting an estimated 5...
1.0K
Attention-Deficit/Hyperactivity Disorder01:30

Attention-Deficit/Hyperactivity Disorder

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
1.3K
Autism Spectrum Disorder01:19

Autism Spectrum Disorder

Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
1.7K
Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
4.5K
Learning Disabilities01:25

Learning Disabilities

Learning disabilities are cognitive disorders caused by neurological impairments that affect cognitive functions like language and reading, without indicating overall intellectual or developmental challenges. These disabilities differ from global intellectual or developmental disabilities as they are limited to distinct cognitive functions. Common learning disabilities include dysgraphia, dyslexia, and dyscalculia, each of which impacts unique aspects of learning.
Dyslexia
Dyslexia is a...
730
Environmental Influences on Intelligence01:29

Environmental Influences on Intelligence

Despite the strong genetic influence on traits like intelligence, environmental factors significantly shape outcomes. For example, while over 90% of height variation is due to genetic differences, environmental factors such as nutrition also have a notable impact. Similarly, for intelligence, changes in a child's surroundings can significantly alter their IQ. Research shows that enriched environments boost children's academic success and help them develop key cognitive skills. Children...
1.1K