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Updated: Mar 22, 2026
The Clinical Application of Tumor Treating Fields Therapy in Glioblastoma
Published on: April 16, 2019
Current and future strategies for treatment of glioma
Nancy Ann Oberheim Bush1, Susan M Chang2, Mitchel S Berger3
1Division of Neuro-Oncology, Department of Neurological Surgery, University of California, San Francisco, CA, USA. Nancyann.oberheimbush@ucsf.edu.
Abstract:
Gliomas are one of the most common types of primary brain tumors and have remained particularly challenging to treat. This review illustrates a multidisciplinary approach to the treatment of glioma and glioblastoma. We will review current advances in surgical approaches, novel imaging techniques, advanced molecular characterization of tumors and translational efforts for treatment. We will focus on current clinical trials as well as the pursuit of personalized or precision therapy. We will also comment on the importance of both quality of life of our patients and their care givers.
Insights
This review covers multidisciplinary strategies for treating gliomas, a challenging brain tumor. It highlights advances in surgery, imaging, molecular analysis, and personalized therapies, emphasizing patient quality of life.
Area of Science:
- Neuro-oncology
- Neurosurgery
- Medical Imaging
Background:
- Gliomas are common primary brain tumors and notoriously difficult to treat.
- Current treatment paradigms for glioma and glioblastoma require multifaceted approaches.
Purpose of the Study:
- To review current advances in the multidisciplinary treatment of glioma and glioblastoma.
- To explore novel surgical techniques, imaging modalities, and molecular characterization.
- To discuss translational research, clinical trials, and personalized medicine strategies.
Main Methods:
- Review of current literature on glioma and glioblastoma treatment.
- Analysis of recent advancements in surgical techniques and neuroimaging.
- Examination of molecular profiling and its therapeutic implications.
- Evaluation of ongoing clinical trials and precision therapy initiatives.
Main Results:
- Multidisciplinary approaches integrating surgery, molecular diagnostics, and targeted therapies show promise.
- Novel imaging and advanced molecular characterization are improving tumor assessment and treatment planning.
- Personalized medicine and ongoing clinical trials are crucial for advancing glioma treatment outcomes.
Conclusions:
- A comprehensive, multidisciplinary strategy is essential for optimizing glioma and glioblastoma treatment.
- Continued research in surgical techniques, molecular biology, and personalized therapies is vital.
- Focusing on patient quality of life is integral to comprehensive cancer care.
