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Structure-function relationships in rat brainstem subnucleus interpolaris: IV. Projection neurons.

M F Jacquin1, M Barcia, R W Rhoades

  • 1Department of Anatomy and Neurobiology, St. Louis University School of Medicine, Missouri 63104.

The Journal of Comparative Neurology
|April 1, 1989
PubMed
Summary

Spinal trigeminal nucleus projection neurons show distinct structures related to their function and targets. Thalamic projecting neurons have larger receptive fields and dendritic trees than cerebellar projecting neurons.

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Area of Science:

  • Neuroscience
  • Cell Biology

Background:

  • Local circuit (LC) neurons in the spinal trigeminal (V) subnucleus interpolaris (Sp Vi) were previously characterized.
  • This study focuses on the structure and function of projection neurons within the same brain region.

Purpose of the Study:

  • To characterize the morphology and functional properties of projection neurons in the Sp Vi.
  • To compare the characteristics of projection neurons based on their target (thalamus, cerebellum, etc.) and sensory input (vibrissae, guard hair, glabrous skin).

Main Methods:

  • Electrophysiological recordings and morphological analyses were performed on 44 Sp Vi projection neurons.
  • Neurons were classified based on their projection target and response to sensory stimuli (vibrissae deflection, guard hair deflection, skin indentation).

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Main Results:

  • The majority of Sp Vi projection neurons responded to vibrissae deflection and typically had multi-vibrissae receptive fields.
  • Projection neurons were larger (cell bodies, dendritic trees, axons) and had more spiny dendrites than LC neurons.
  • Dendritic tree extent significantly correlated with receptive field size in vibrissae-sensitive neurons.
  • Thalamic projecting neurons had larger receptive fields and dendritic trees, and more local axon collaterals than cerebellar projecting neurons.

Conclusions:

  • Structure-function relationships are evident in Sp Vi projection neurons.
  • Receptive field size and projection target are key parameters correlating with the morphology of vibrissae-sensitive projection neurons.