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Mitochondrial Biogenesis Inhibitors for Anticancer Therapy: A Review of Recent Patents

Jinzheng Wang, Xiaoan Wen, Jun Liu1

  • 1. junincpu@yahoo.com.

Recent Patents on Anti-Cancer Drug Discovery
|April 19, 2016
PubMed

Insights

Inhibiting mitochondrial biogenesis may offer a novel cancer therapy by starving cancer cells. This review covers small molecule inhibitors targeting key regulators of tumor mitochondrial growth.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Enhanced mitochondrial biogenesis fuels cancer cell growth and migration.
  • Targeting cellular energy production presents a potential therapeutic strategy for cancer.

Purpose of the Study:

  • To review recent patents and research on small molecule inhibitors of tumor mitochondrial biogenesis.
  • To identify key regulators of mitochondrial biogenesis as therapeutic targets in cancer.

Main Methods:

  • Literature review of scientific papers and patents.
  • Focus on small molecule inhibitors targeting specific regulatory proteins.

Main Results:

  • Identification of key regulators: PPARγcoactivator-1α (PGC-1α), PPARγcoactivator-1β, estrogen-related receptor family (ERRs), estrogen receptor α (ERα), mTOR, c-Myc, and PPARs.
  • Summary of current developments in small molecule inhibitor research for these targets.

Conclusions:

  • Inhibiting mitochondrial biogenesis is a promising avenue for cancer therapy.
  • Development of small molecule inhibitors targeting key regulators shows potential for clinical application.

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