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[EVALUATION OF DYSFUNCTION IN BLOOD COAGULATION IN CHILDREN WITH URTICARIA]

Koji Nishimura1, Kazuyo Kuzume, Yuki Kagata

  • 1Department of Pediatrics, Ehime University Graduate School of Medicine.

Arerugi = [Allergy]
|April 19, 2016
PubMed

Insights

Prothrombin fragments 1+2 (PTF1+2) levels are elevated in active urticaria in children. These levels, along with fibrin degradation product (FDP) and D-dimer, decrease as urticaria symptoms improve, indicating their potential as biomarkers.

Area of Science:

  • Pediatric Hematology
  • Dermatology
  • Coagulation Science

Context:

  • Urticaria is a common dermatological condition with a known association with coagulation dysfunction.
  • Research specifically examining coagulation markers in pediatric urticaria is limited.
  • Understanding these associations can improve diagnostic and prognostic capabilities.

Purpose:

  • To investigate coagulation markers in children with different types of urticaria.
  • To determine if specific coagulation markers correlate with urticaria activity.
  • To explore the utility of these markers in assessing disease severity.

Summary:

  • Prothrombin fragments 1+2 (PTF1+2) levels were significantly higher in children with active chronic urticaria and acute urticaria compared to inactive chronic urticaria.
  • No significant differences in fibrin degradation product (FDP), D-dimer, or mean platelet volume (MPV) were found among the groups.
  • Levels of PTF1+2, FDP, and D-dimer decreased as urticaria symptoms resolved.

Impact:

  • Plasma PTF1+2 levels may serve as a valuable biomarker for assessing urticaria activity in pediatric patients.
  • This finding could lead to more objective measures of disease severity and treatment response.
  • Further research can validate these markers for clinical application in pediatric dermatology.
Abstract

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