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Related Concept Videos

Fatigue01:21

Fatigue

994
Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...
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Muscle Recovery and Fatigue01:24

Muscle Recovery and Fatigue

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Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective...
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Myasthenia Gravis: Overview and Treatment01:20

Myasthenia Gravis: Overview and Treatment

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Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
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Heart Failure VII: Nursing Interventions01:30

Heart Failure VII: Nursing Interventions

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The first step in nursing management of a patient with heart failure involves thoroughly assessing the patient's medical history.Subjective Data: Obtain the patient's medical history of coronary artery disease, hypertension, myocardial infarction, and symptoms like dyspnea, orthopnea, and paroxysmal nocturnal dyspnea.Objective Data: Conduct a physical examination to identify findings such as jugular vein distention, pulmonary crackles, tachycardia, murmurs, peripheral edema, and vital signs,...
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Cardiomyopathy VI: Nursing Management01:29

Cardiomyopathy VI: Nursing Management

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Assessment: Nursing management of patients with cardiomyopathy begins with a thorough assessment of the patient's history, including a family history of cardiomyopathy or sudden cardiac death, personal history of heart disease, hypertension, diabetes, and any alcohol consumption or drug use.During the physical examination, assess vital signs, look for signs of heart failure (such as edema, jugular venous distention, and cyanosis), auscultate for abnormal heart sounds (like murmurs and gallops),...
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COPD: Management Using Bronchodilators and Corticosteroids01:26

COPD: Management Using Bronchodilators and Corticosteroids

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Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
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Related Experiment Video

Updated: Mar 22, 2026

The Effect of Anti-Fatigue Decoction on the Behaviors and Serological Indicators in a Central Fatigue Rat Model
05:38

The Effect of Anti-Fatigue Decoction on the Behaviors and Serological Indicators in a Central Fatigue Rat Model

Published on: April 12, 2024

632

Fatigue Management in Multiple Sclerosis.

Carmen Tur1,2

  • 1National Hospital for Neurology and Neurosurgery, Queen Square, London, UK. c.tur@ucl.ac.uk.

Current Treatment Options in Neurology
|April 19, 2016
PubMed
Summary
This summary is machine-generated.

Early diagnosis and treatment of multiple sclerosis (MS) fatigue are crucial. A multidisciplinary approach, including non-pharmacological interventions, is recommended for managing MS-related fatigue effectively.

Keywords:
Cognitive behavioural therapyDisabilityEXIMSEnergy conservation education programmesExerciseFACETSFSSFatigueMFISMindfulness interventionMultidisciplinary approachMultiple sclerosisNICE guidelinesVAS

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Area of Science:

  • Neurology
  • Rehabilitation Medicine

Background:

  • Multiple sclerosis (MS) is a central nervous system inflammatory disease causing long-term disability.
  • MS-related fatigue is a common and disabling symptom, often as severe as objective neurological deficits.
  • Early diagnosis and management of MS fatigue are essential.

Purpose of the Study:

  • To outline the importance of early diagnosis and management of fatigue in multiple sclerosis.
  • To discuss the role of a multidisciplinary team in assessing and treating MS-related fatigue.
  • To review current pharmacological and non-pharmacological treatment options for MS-related fatigue.

Main Methods:

  • Assessment involves ruling out MS-related and unrelated causes of fatigue.
  • Therapeutic interventions include pharmacological and non-pharmacological approaches.
  • Non-pharmacological interventions encompass physical, psychological, and mixed approaches.

Main Results:

  • Amantadine is the only currently recommended pharmacological treatment for MS-related fatigue.
  • Randomized clinical trials support the efficacy of various non-pharmacological interventions.
  • Mixed physical/psychological interventions show promise for improving fatigue and general MS aspects.

Conclusions:

  • A multidisciplinary team approach is vital for managing MS-related fatigue.
  • Non-pharmacological strategies, particularly mixed approaches, are effective for treating MS fatigue.
  • Comprehensive management improves fatigue levels and overall well-being in MS patients.