Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cluster Sampling Method01:20

Cluster Sampling Method

15.4K
Appropriate sampling methods ensure that samples are drawn without bias and accurately represent the population. Because measuring the entire population in a study is not practical, researchers use samples to represent the population of interest.
To choose a cluster sample, divide the population into clusters (groups) and then randomly select some of the clusters. All the members from these clusters are in the cluster sample. For example, if you randomly sample four departments from your...
15.4K
Extraction: Partition and Distribution Coefficients01:14

Extraction: Partition and Distribution Coefficients

5.4K
The distribution law or Nernst's distribution law is the law that governs the distribution of a solute between two immiscible solvents. This law, also known as the partition law, states that if a solute is added to the mixture of two immiscible solvents at a constant temperature, the solute is distributed between the two solvents in such a way that the ratio of solute concentrations in the solvents remains constant at equilibrium.
For extracting a solute from an aqueous phase into an...
5.4K
¹H NMR: Complex Splitting01:13

¹H NMR: Complex Splitting

2.1K
A proton M that is coupled to a proton X results in doublet signals for M. However, NMR-active nuclei can be simultaneously coupled to more than one nonequivalent nucleus. When M is coupled to a second proton A, such as in styrene oxide, each peak in the doublet is split into another doublet.
Splitting diagrams or splitting tree diagrams are routinely used to depict such complex couplings. While drawing splitting diagrams, the splitting with the larger coupling constant is usually applied...
2.1K
One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation01:24

One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation

1.4K
This lesson introduces two critical methods in pharmacokinetics, the Wagner-Nelson and Loo-Riegelman methods, used for estimating the absorption rate constant (ka) for drugs administered via non-intravenous routes. The Wagner-Nelson method relates ka to the plasma concentration derived from the slope of a semilog percent unabsorbed time plot. However, it is limited to drugs with one-compartment kinetics and can be impacted by factors like gastrointestinal motility or enzymatic degradation.
On...
1.4K
¹H NMR Signal Multiplicity: Splitting Patterns01:13

¹H NMR Signal Multiplicity: Splitting Patterns

8.4K
When protons A and X are coupled, their nuclear spin energy levels are slightly modified. This is because the energy required to excite proton A to a spin state parallel to proton X is slightly different from the energy required for it to become anti-parallel to spin X. Consequently, there are two possible excitation frequencies for A (A1 and A2), depending on the spin state of X, and vice versa. The mutual nature of coupling implies that the difference between frequencies A1 and A2, indicated...
8.4K
Extraction: Advanced Methods00:56

Extraction: Advanced Methods

1.3K
Metal ions can be separated from one another by complexation with organic ligands–the chelating agent– to form uncharged chelates. Here, the chelating agent must contain hydrophobic groups and behave as a weak acid, losing a proton to bind with the metal. Since most organic ligands used in this process are insoluble or undergo oxidation in the aqueous phase, the chelating agent is initially added to the organic phase and extracted into the aqueous phase. The metal-ligand complex is...
1.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Simulation-based machine learning for real-time assessment of side-branch hemodynamics in coronary bifurcation lesions.

The international journal of high performance computing applications·2026
Same author

mGEM: multigraph estimation models for pattern analysis.

BMC bioinformatics·2026
Same author

An approximate-copula distribution for statistical modeling.

PLoS computational biology·2026
Same author

Generalizations of the quadratic bound optimization principle.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Transfer Learning for Survival-based Clustering of Predictors with an Application to <i>TP53</i> Mutation Annotation.

bioRxiv : the preprint server for biology·2025
Same author

Closest Farthest Widest.

Algorithms·2025
Same journal

Probabilistic Joint and Individual Variation Explained (ProJIVE) for Data Integration.

Journal of computational and graphical statistics : a joint publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America·2026
Same journal

fastkqr: A Fast Algorithm for Kernel Quantile Regression.

Journal of computational and graphical statistics : a joint publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America·2026
Same journal

Empirical Bayes Covariance Decomposition, and a Solution to the Multiple Tuning Problem in Sparse PCA.

Journal of computational and graphical statistics : a joint publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America·2026
Same journal

Joint Registration and Conformal Prediction for Partially Observed Functional Data.

Journal of computational and graphical statistics : a joint publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America·2026
Same journal

Efficient Decision Trees for Tensor Regressions.

Journal of computational and graphical statistics : a joint publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America·2026
Same journal

Distributed Nonparametric Regression with Heterogeneity Through Prediction-Based Aggregation.

Journal of computational and graphical statistics : a joint publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America·2026
See all related articles

Related Experiment Video

Updated: Mar 22, 2026

Spatial Separation of Molecular Conformers and Clusters
10:37

Spatial Separation of Molecular Conformers and Clusters

Published on: January 9, 2014

11.9K

Splitting Methods for Convex Clustering.

Eric C Chi1, Kenneth Lange2

  • 1Postdoctoral Research Associate, Department of Electrical and Computer Engineering, Rice University, Houston, TX 77005.

Journal of Computational and Graphical Statistics : a Joint Publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America
|April 19, 2016
PubMed
Summary
This summary is machine-generated.

New splitting algorithms, alternating direction method of multipliers (ADMM) and alternating minimization algorithm (AMA), solve convex clustering problems. AMA demonstrates superior efficiency in numerical experiments for clustering data.

Keywords:
Alternating direction method of multipliersAlternating minimization algorithmConvex optimizationHierarchical clusteringRegularization pathsk-means

More Related Videos

A Visual Guide to Sorting Electrophysiological Recordings Using 'SpikeSorter'
10:31

A Visual Guide to Sorting Electrophysiological Recordings Using 'SpikeSorter'

Published on: February 10, 2017

11.7K
Large-scale Reconstructions and Independent, Unbiased Clustering Based on Morphological Metrics to Classify Neurons in Selective Populations
12:27

Large-scale Reconstructions and Independent, Unbiased Clustering Based on Morphological Metrics to Classify Neurons in Selective Populations

Published on: February 15, 2017

7.4K

Related Experiment Videos

Last Updated: Mar 22, 2026

Spatial Separation of Molecular Conformers and Clusters
10:37

Spatial Separation of Molecular Conformers and Clusters

Published on: January 9, 2014

11.9K
A Visual Guide to Sorting Electrophysiological Recordings Using 'SpikeSorter'
10:31

A Visual Guide to Sorting Electrophysiological Recordings Using 'SpikeSorter'

Published on: February 10, 2017

11.7K
Large-scale Reconstructions and Independent, Unbiased Clustering Based on Morphological Metrics to Classify Neurons in Selective Populations
12:27

Large-scale Reconstructions and Independent, Unbiased Clustering Based on Morphological Metrics to Classify Neurons in Selective Populations

Published on: February 15, 2017

7.4K

Area of Science:

  • Computational Science
  • Data Mining
  • Machine Learning

Background:

  • Clustering is essential in scientific applications, but standard methods like k-means suffer from local minima.
  • Convex relaxations of clustering methods address local minima by ensuring a unique global minimizer.
  • Existing algorithms for convex clustering can be complex and limited in scope.

Purpose of the Study:

  • To introduce novel splitting algorithms for solving the convex clustering problem.
  • To provide unified frameworks for convex clustering applicable to various norms.
  • To compare the efficiency of the proposed algorithms.

Main Methods:

  • Developed two splitting methods: Alternating Direction Method of Multipliers (ADMM) and Alternating Minimization Algorithm (AMA).
  • Formulated ADMM and AMA to solve convex clustering problems under various norms.
  • Evaluated algorithm performance using simulated and real-world datasets.

Main Results:

  • Both ADMM and AMA provide simple and unified frameworks for convex clustering.
  • Numerical experiments and complexity analysis reveal AMA as significantly more efficient than ADMM.
  • The proposed methods successfully handle convex clustering problems, including potential novel norms.

Conclusions:

  • The developed ADMM and AMA algorithms offer effective solutions for convex clustering.
  • AMA is identified as a more computationally efficient algorithm for convex clustering tasks.
  • These methods advance the field by providing flexible and efficient tools for data analysis.