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Cardiovascular autonomic function in multiple sclerosis.

A M Nordenbo1, F Boesen, E B Andersen

  • 1Department of Neurology, University Hospital, Rigshospitalet, Copenhagen, Denmark.

Journal of the Autonomic Nervous System
|February 1, 1989
PubMed
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Cardiovascular autonomic nervous system function is subtly impaired in multiple sclerosis patients, affecting both parasympathetic and sympathetic responses. These autonomic dysfunctions show minimal correlation with clinical disease severity.

Area of Science:

  • Cardiovascular physiology
  • Autonomic nervous system function
  • Neurology

Background:

  • Multiple sclerosis (MS) is a chronic demyelinating disease affecting the central nervous system.
  • Cardiovascular autonomic dysfunction is a potential complication of MS, impacting patient quality of life.
  • Non-invasive assessment of autonomic function provides valuable insights into cardiovascular regulation in neurological disorders.

Purpose of the Study:

  • To investigate cardiovascular autonomic nervous system function in multiple sclerosis patients.
  • To compare autonomic function in MS patients with healthy controls.
  • To explore correlations between autonomic abnormalities and clinical manifestations in MS.

Main Methods:

  • Non-invasive cardiovascular autonomic function tests were employed.

Related Experiment Videos

  • Participants included 30 multiple sclerosis patients and 30 age-matched healthy controls.
  • Tests included heart rate variation during deep breathing, orthostatic procedures, and sustained handgrip.

    • Main Results:

    • Reduced heart rate variation during deep breathing indicated parasympathetic impairment.
    • Over half of MS patients exhibited abnormal orthostatic responses, primarily increased heart rate.
    • Decreased blood pressure response during sustained handgrip suggested sympathetic dysfunction.

    Conclusions:

    • Subtle abnormalities in parasympathetic and sympathetic cardiovascular autonomic function are present in multiple sclerosis.
    • Autonomic dysfunction in MS patients is not strongly correlated with other clinical signs and symptoms.
    • Non-invasive autonomic function testing is a useful tool for evaluating cardiovascular health in MS.