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Inflammatory Bowel Disease II: Crohn's Disease01:30

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Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
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Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF01:24

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Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
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Chronic Salmonella Infection Induced Intestinal Fibrosis
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Crohn's disease and skin.

A G Gravina1, A Federico1, E Ruocco2

  • 1Department of Clinical and Experimental Medicine 'Magrassi-Lanzara', Gastroenterology Unit, Second University of Naples, Italy.

United European Gastroenterology Journal
|April 19, 2016
PubMed
Summary

Crohn's disease, an inflammatory bowel condition, can cause skin issues in many patients. This review focuses on these dermatological effects, especially those linked to anti-tumour necrosis factor treatments.

Keywords:
Crohn’s diseaseanti-tumour necrosis factor-alphadermatologic manifestationinflammatory bowel disease

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Area of Science:

  • Gastroenterology
  • Dermatology
  • Immunology

Background:

  • Crohn's disease is a chronic inflammatory bowel disease affecting the GI tract.
  • Extra-intestinal manifestations occur in 6%-40% of patients.
  • Skin disorders are common extra-intestinal manifestations of Crohn's disease.

Purpose of the Study:

  • To review the spectrum of skin manifestations associated with Crohn's disease.
  • To specifically examine skin lesions related to anti-tumour necrosis factor (TNF) therapy.

Main Methods:

  • Literature review of studies on Crohn's disease and its skin manifestations.
  • Focus on clinical presentations and treatment associations.

Main Results:

  • Skin manifestations are frequent in Crohn's disease patients.
  • Anti-TNF therapy is associated with specific types of skin lesions.

Conclusions:

  • Dermatological conditions are a significant aspect of Crohn's disease management.
  • Understanding therapy-associated skin lesions is crucial for patient care.