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Oxidative Stress: A Promising Target for Chemoprevention

Am Sashi Papu John1, Murali K Ankem1, Chendil Damodaran1

  • 1Department of Urology, University of Louisville, KY 40202.

Current Pharmacology Reports
|April 19, 2016
PubMed

Insights

Dietary agents with antioxidant properties show promise in combating cancer by targeting oxidative stress and DNA damage. These natural compounds offer a potential strategy for cancer chemoprevention and therapy, with some progressing to clinical trials.

Area of Science:

  • Oncology
  • Nutritional Science
  • Biochemistry

Background:

  • Cancer remains a significant global health challenge, particularly in advanced stages.
  • Oxidative stress, driven by oxidants and free radicals, is a key factor in cancer development and DNA damage.
  • Dietary agents with antioxidant properties present a promising avenue for cancer prevention and treatment.

Purpose of the Study:

  • To explore the potential of dietary agents in targeting oxidative stress for cancer chemoprevention and therapy.
  • To review the role of antioxidants in mitigating DNA damage associated with cancer pathogenesis.
  • To highlight dietary agents currently under investigation for cancer treatment.

Main Methods:

  • Review of epidemiological studies on cancer pathogenesis and oxidative stress.
  • Analysis of scientific literature on dietary agents and their antioxidant mechanisms.
  • Examination of the current status of dietary agents in cancer research and clinical trials.

Main Results:

  • Dietary agents can effectively target oxidative stress, a primary cause of cancer.
  • Antioxidant properties of these agents can delay, prevent, or treat cancer development.
  • Several dietary agents are progressing from basic research to clinical trials.

Conclusions:

  • Dietary agents represent a viable strategy for cancer chemoprevention and therapy by modulating oxidative stress.
  • Harnessing the power of antioxidants in diet can play a crucial role in managing cancer progression.
  • Further research and clinical trials are essential to fully realize the therapeutic potential of these agents.

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