Experimental trichinosis in alloxan induced diabetes in mice

The course of Trichinella spiralis infection was studied in Alloxan induced diabetes in mice. The number of Trichinella larvae in muscles of infected animals was estimated by digestion of whole carcases and compared with control non diabetic group. Histopathological study of infected muscles was also done. It was found that diabetic mice developed very heavy muscle parasitism and their larval count was high compared with non diabetic animals. Besides, there was heavy inflammatory cellular reaction around poorly encapsulated larvae. Mortality rate was 100% by day 45 in diabetic mice while control animals survived during the period of observation which was 3 months. These data indicated that hyperglycaemia significantly increased parasitisaemia and mortality in mice infected with T. spiralis.