Mangiferin: a promising anticancer bioactive

Area of Science:

• Natural Product Chemistry
• Pharmacology
• Oncology

Background:

• Oxidative stress is a key factor in carcinogenesis.
• Natural antioxidants are investigated for cancer prevention.
• Mangiferin, a polyphenol from Mangifera indica, possesses antioxidant properties.

Purpose of the Study:

• To review patents on mangiferin's chemopreventive action.
• To summarize mangiferin's role in apoptosis induction in cancer cells.
• To explore mangiferin's antioxidative activities and molecular targets.

Main Methods:

• Literature review of patents and scientific publications.
• Analysis of mangiferin's chemical structure and properties.
• Summary of experimental data on mangiferin's biological effects.

Main Results:

• Mangiferin exhibits significant antioxidant and anti-inflammatory properties.
• Patents demonstrate mangiferin's potential in chemoprevention.
• Mangiferin induces apoptosis in various cancer cell lines.
• Diverse molecular targets of mangiferin have been identified.

Conclusions:

• Mangiferin is a promising natural compound for cancer prevention.
• Further research into mangiferin's therapeutic applications is warranted.
• Mangiferin's multifaceted action makes it a valuable candidate for drug development.