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Updated: Mar 22, 2026

Stable Isotope In-Vivo Labeling for Mass-Spectrometry Identification of Paternal Metabolites Transferred from Sperm to Oocyte During Fertilization
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Stable Isotope In-Vivo Labeling for Mass-Spectrometry Identification of Paternal Metabolites Transferred from Sperm to Oocyte During Fertilization

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Intra- and inter-individual differences in human sperm DNA methylation.

E Dere1,2, S Huse2, K Hwang1,3

  • 1Division of Urology, Rhode Island Hospital, Providence, RI, USA.

Andrology
|April 19, 2016
PubMed
Summary
This summary is machine-generated.

Sperm DNA methylation is crucial for reproductive health. This study found that sperm methylation levels are highly stable within individuals and between samples, indicating consistent epigenetic patterns.

Keywords:
DNA methylationepigeneticssemen analysis

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Area of Science:

  • Reproductive Biology
  • Epigenetics
  • Sperm Health

Background:

  • Sperm DNA methylation plays a role in sperm health and function.
  • Limited data exists on the variability of sperm DNA methylation levels within and between individuals.

Purpose of the Study:

  • To characterize the intra- and inter-individual variability of sperm DNA methylation.
  • To assess the stability of sperm epigenetic patterns over time.

Main Methods:

  • Analysis of sperm DNA methylation using Illumina Infinium HumanMethylation450 BeadChips.
  • Examination of successive semen samples from 12 patients.
  • Global and regional genomic methylation analysis.

Main Results:

  • Sperm DNA methylation levels exhibited a bimodal distribution, unevenly spread across genomic regions.
  • High correlations were observed in both intra- and inter-individual methylation comparisons.
  • Intra-individual methylation levels showed stronger correlations than inter-individual levels, signifying stability.

Conclusions:

  • Sperm DNA methylation levels are relatively stable between semen sample collections.
  • Individual sperm epigenetic profiles demonstrate consistency over time.
  • These findings contribute to understanding sperm epigenetics and its implications for fertility.