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Related Concept Videos

Overview of Cell-Matrix Interactions01:24

Overview of Cell-Matrix Interactions

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The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
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Cell Adhesion Molecules - Types and Functions01:20

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Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
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Cell Adhesion Molecules - Types and Functions01:20

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Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

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Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
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Adhesion01:14

Adhesion

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Adhesion occurs when one type of molecule is attracted to a different molecule. Water exhibits adhesive properties in the presence of polar surfaces, such as glass or cellulose in plants. For instance, when water is poured into a glass, the positively charged hydrogen molecules of water are more attracted to the negatively charged oxygen molecules in the silica than to the oxygen in neighboring water molecules.
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Cell-matrix's Response to Mechanical Forces01:13

Cell-matrix's Response to Mechanical Forces

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In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue. 
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Analyzing Cell Surface Adhesion Remodeling in Response to Mechanical Tension Using Magnetic Beads
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Cell Adhesion on Surface-Functionalized Magnesium.

Victoria Wagener1, Achim Schilling2, Astrid Mainka2

  • 1Chair for Surface Science and Corrosion, Department of Materials Science, University Erlangen-Nuremberg , Martensstrasse 7, 91058 Erlangen, Germany.

ACS Applied Materials & Interfaces
|April 19, 2016
PubMed
Summary
This summary is machine-generated.

Organic coatings like aminopropyltriethoxysilane + vitamin C (AV) significantly improve the biocompatibility of magnesium (Mg) implants. AV coatings enhance long-term cell growth and reduce hydrogen evolution, crucial for biodegradable medical devices.

Keywords:
cell adhesioncorrosion protectionimpedance spectroscopymagnesiumorganic coating

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Area of Science:

  • Biomaterials Science
  • Surface Chemistry
  • Tissue Engineering

Background:

  • Commercially pure magnesium (cp Mg) biodegradable implants face biocompatibility issues due to rapid corrosion, causing hydrogen evolution and surface alkalization.
  • Strategies to mitigate corrosion include alloying elements or surface coatings to enhance protein adsorption and cell adhesion.

Purpose of the Study:

  • To investigate the effect of specific organic coatings on the long-term cell growth and biocompatibility of cp Mg implants.
  • To evaluate the corrosion resistance of coated cp Mg in a physiological environment during cell culture.

Main Methods:

  • cp Mg samples were coated with aminopropyltriethoxysilane + vitamin C (AV), carbonyldiimidazole (CDI), or stearic acid (SA).
  • Endothelial cells (DH1+/+) and osteosarcoma cells (MG63) were cultured on coated and uncoated samples for up to 20 days.
  • Electrochemical impedance spectroscopy (EIS) quantified Mg corrosion, and cell spreading was assessed using fluorescently labeled fibroblasts (NIH/3T3).

Main Results:

  • AV and SA coatings markedly decreased hydrogen evolution compared to uncoated Mg.
  • AV and SA coatings promoted cell adhesion and spreading within 24 hours, comparable to tissue-treated plastic.
  • A confluent layer of endothelial cells formed on AV-coated cp Mg within 5 days and persisted for 20 days.
  • EIS confirmed that a confluent cell layer enhanced the corrosion resistance of the Mg surface.

Conclusions:

  • Surface coating with AV is a viable strategy to improve the long-term biocompatibility of cp Mg biodegradable implants.
  • The AV coating effectively reduces initial corrosion and supports sustained cell growth, addressing key limitations of Mg-based implants.