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Related Concept Videos

Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

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Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
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Nephrons01:10

Nephrons

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The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
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Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

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Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
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Chronic Kidney Disease IV: Nursing Management01:18

Chronic Kidney Disease IV: Nursing Management

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Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of...
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Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

909
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
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Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

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Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
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Related Experiment Video

Updated: Mar 22, 2026

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
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5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

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NAFLD and Chronic Kidney Disease.

Morgan Marcuccilli1, Michel Chonchol2

  • 1Division of Renal Diseases and Hypertension, University of Colorado Hospital, Aurora, CO 80045, USA. morgan.marcuccilli@ucdenver.edu.

International Journal of Molecular Sciences
|April 19, 2016
PubMed
Summary

Non-alcoholic fatty liver disease (NAFLD) is linked to chronic kidney disease (CKD) development. Understanding shared inflammatory pathways like obesity and metabolic dysregulation is key for new NAFLD and CKD therapies.

Keywords:
chronic kidney diseaseinflammationnon-alcoholic fatty liver diseasenon-alcoholic steatohepatitisreview

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Assessment of Vascular Function in Patients With Chronic Kidney Disease
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Assessment of Vascular Function in Patients With Chronic Kidney Disease
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Area of Science:

  • Hepatology
  • Nephrology
  • Metabolic Disorders

Background:

  • Non-alcoholic fatty liver disease (NAFLD) is a prevalent liver condition.
  • NAFLD is increasingly recognized as a risk factor for cardiovascular disease.
  • Emerging evidence suggests a link between NAFLD and chronic kidney disease (CKD).

Purpose of the Study:

  • To review recent literature on NAFLD diagnosis.
  • To explore the pathophysiology linking NAFLD and CKD.
  • To identify potential therapeutic targets for co-occurring NAFLD and CKD.

Main Methods:

  • Review of recent scientific publications.
  • Analysis of cross-sectional and case-control studies.
  • Discussion of emerging pathophysiological mechanisms.

Main Results:

  • NAFLD and CKD share common inflammatory pathways.
  • Obesity, renin-angiotensin system, and fructose metabolism are implicated.
  • Dysregulation of lipogenesis contributes to both conditions.

Conclusions:

  • NAFLD and CKD may be viewed as interconnected inflammatory disorders.
  • Further research into shared pathways could yield novel therapeutic strategies.
  • Prospective studies with renal and liver histology are needed to clarify the relationship.