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Updated: Mar 22, 2026

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
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Acute Sleep Deprivation Induces a Local Brain Transfer Information Increase in the Frontal Cortex in a Widespread

Joan F Alonso1,2,3, Sergio Romero4,5, Miguel A Mañanas6,7,8

  • 1Biomedical Engineering Research Centre, Department of Automatic Control, Universitat Politècnica de Catalunya, Barcelona 08028, Spain. joan.francesc.alonso@upc.edu.

Sensors (Basel, Switzerland)
|April 19, 2016
PubMed
Summary
This summary is machine-generated.

Sleep deprivation significantly alters brain information flow, decreasing long-range connections and increasing local frontal activity. Transfer entropy (TE) offers an objective measure of sleep pressure and somnolence.

Keywords:
electroencephalography (EEG) transfer entropy (TE)prolonged wakefulnesssleep deprivation (SD)

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Area of Science:

  • Neuroscience
  • Cognitive Science
  • Signal Processing

Background:

  • Sleep deprivation (SD) negatively impacts cognitive functions, alertness, and emotional regulation.
  • Understanding the neural mechanisms underlying these effects is crucial for public health.
  • Scalp electroencephalography (EEG) provides a window into brain activity.

Purpose of the Study:

  • To investigate the directional information transfer in scalp EEG signals following sleep deprivation.
  • To assess the utility of transfer entropy (TE) as a measure of brain network changes during SD.
  • To correlate brain connectivity measures with subjective somnolence.

Main Methods:

  • EEG data were collected from 18 volunteers subjected to 36 hours of sleep deprivation.
  • Transfer entropy (TE) and spectral analysis were applied to EEG data acquired every 2 hours.
  • Connectivity measures were correlated with subjective somnolence ratings.

Main Results:

  • TE revealed significant decreases in medium- and long-range information transfer, originating from occipital areas.
  • Short-range increases in information transfer were observed in frontal areas after 20 hours of SD.
  • These changes indicate diminished global brain integration and increased local connectivity.

Conclusions:

  • Transfer entropy effectively quantifies changes in brain network dynamics during sleep deprivation.
  • TE demonstrates potential as an objective measure for assessing sleep pressure and somnolence.
  • The findings highlight the directed nature of information flow alterations in the brain under SD.